Protein Name EPH receptor B2
Organism Homo sapiens
Gene ID 2048
Gene Symbol

EPHB2

UniProt P29323 (EPHB2_HUMAN), Q6NVW1 (Q6NVW1_HUMAN), B4DSE0 (B4DSE0_HUMAN), Q4LE53 (Q4LE53_HUMAN)
Relationships Total Number of functionally related compound(s) : 321
Total Number of Articles : 455
Description

EPH receptor B2

Gene Summary

This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

synonyms
  • ephrin type-B receptor 2
  • EPH-like kinase 5
  • developmentally-regulated Eph-related tyrosine kinase
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Properties