Sorafenib

AKT serine/threonine kinase 1 ; Homo sapiens







154 Article(s)
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1 32391926 Sorafenib induces pigmentation via the regulation of β-catenin signalling pathway in melanoma cells. 2022 Jan 4
2 35111229 Citrus Flavone Tangeretin Inhibits CRPC Cell Proliferation by Regulating Cx26, AKT, and AR Signaling. 2022 1
3 35244188 DYRK1A suppression attenuates HIF‑1α accumulation and enhances the anti‑liver cancer effects of regorafenib and sorafenib under hypoxic conditions. 2022 Apr 1
4 35359392 Knockdown of AKR1C3 Promoted Sorafenib Sensitivity Through Inhibiting the Phosphorylation of AKT in Hepatocellular Carcinoma. 2022 2
5 32510618 The aryl hydrocarbon receptor ligand ITE inhibits cell proliferation and migration and enhances sensitivity to drug-resistance in hepatocellular carcinoma. 2021 Jan 2
6 33015852 Valproic acid reverses sorafenib resistance through inhibiting activated Notch/Akt signaling pathway in hepatocellular carcinoma. 2021 Aug 7
7 33517269 Urokinase-type Plasminogen Activator Is a Therapeutic Target for Overcoming Sorafenib Resistance in Hepatoma Cells. 2021 Feb 1
8 33667419 Computational model of cardiomyocyte apoptosis identifies mechanisms of tyrosine kinase inhibitor-induced cardiotoxicity. 2021 Jun 1
9 33735117 Enhanced anticancer activity by the combination of vinpocetine and sorafenib via PI3K/AKT/GSK-3β signaling axis in hepatocellular carcinoma cells. 2021 Aug 1 1
10 33776476 Erratum: Oridonin Sensitizes Hepatocellular Carcinoma to the Anticancer Effect of Sorafenib by Targeting the Akt Pathway [Corrigendum]. 2021 1
11 33951569 Pristimerin synergistically sensitizes conditionally reprogrammed patient derived-primary hepatocellular carcinoma cells to sorafenib through endoplasmic reticulum stress and ROS generation by modulating Akt/FoxO1/p27kip1 signaling pathway. 2021 Jun 1
12 33987439 BEZ235 Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Inhibiting PI3K/AKT/mTOR and Inducing Autophagy. 2021 3
13 34026624 Combined Anti-Cancer Effects of Platycodin D and Sorafenib on Androgen-Independent and PTEN-Deficient Prostate Cancer. 2021 1
14 34030133 NUPR1 is a novel potential biomarker and confers resistance to sorafenib in clear cell renal cell carcinoma by increasing stemness and targeting the PTEN/AKT/mTOR pathway. 2021 May 24 1
15 34076140 MicroRNA-92b augments sorafenib resistance in hepatocellular carcinoma via targeting PTEN to activate PI3K/AKT/mTOR signaling. 2021 2
16 34366628 Y-box binding protein 1 augments sorafenib resistance via the PI3K/Akt signaling pathway in hepatocellular carcinoma. 2021 Jul 28 3
17 34377232 Phenformin synergistically sensitizes liver cancer cells to sorafenib by downregulating CRAF/ERK and PI3K/AKT/mTOR pathways. 2021 3
18 34445279 Secretory NPC2 Protein-Mediated Free Cholesterol Levels Were Correlated with the Sorafenib Response in Hepatocellular Carcinoma. 2021 Aug 9 1
19 34632072 Aberrant expression of PI3K/AKT signaling is involved in apoptosis resistance of hepatocellular carcinoma. 2021 1
20 34725436 EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma. 2021 Nov 1 1
21 34765572 CYP2C8 Suppress Proliferation, Migration, Invasion and Sorafenib Resistance of Hepatocellular Carcinoma via PI3K/Akt/p27kip1 Axis. 2021 2
22 34768109 ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma. 2021 Dec 1
23 34852817 Correction to: LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells. 2021 Dec 1 1
24 34916846 Hypoxia-Induced Aquaporin-3 Changes Hepatocellular Carcinoma Cell Sensitivity to Sorafenib by Activating the PI3K/Akt Signaling Pathway [Retraction]. 2021 1
25 34950583 SENP2 Reduces Hepatocellular Carcinoma Stemness and Improves Sorafenib Sensitivity Through Inactivating the AKT/GSK3β/CTNNB1 Pathway. 2021 4
26 32203105 Quantitative phosphoproteomic analysis identifies the potential therapeutic target EphA2 for overcoming sorafenib resistance in hepatocellular carcinoma cells. 2020 Mar 1
27 32461380 LncRNA NEAT1 modulates sorafenib resistance in hepatocellular carcinoma through regulating the miR-149-5p/AKT1 axis. 2020 May 26 1
28 32504550 Neratinib decreases pro-survival responses of [sorafenib + vorinostat] in pancreatic cancer. 2020 Aug 1
29 32606928 Hypoxia-Induced Aquaporin-3 Changes Hepatocellular Carcinoma Cell Sensitivity to Sorafenib by Activating the PI3K/Akt Signaling Pathway. 2020 1
30 32970612 GHR knockdown enhances the sensitivity of HCC cells to sorafenib. 2020 Sep 24 1
31 32982405 Oridonin Sensitizes Hepatocellular Carcinoma to the Anticancer Effect of Sorafenib by Targeting the Akt Pathway. 2020 1
32 33051131 Torin2 overcomes sorafenib resistance via suppressing mTORC2-AKT-BAD pathway in hepatocellular carcinoma cells. 2020 Dec 7
33 33097691 The miR-30a-5p/CLCF1 axis regulates sorafenib resistance and aerobic glycolysis in hepatocellular carcinoma. 2020 Oct 23 1
34 33112540 Effect of Combined Sorafenib/Cisplatinum Treatment on the Autophagy and Proliferation of Hepatocellular Carcinoma hepG2 Cells in Vitro. 2020 Oct 1 2
35 33163195 Upregulation of PD-L1 expression promotes epithelial-to-mesenchymal transition in sorafenib-resistant hepatocellular carcinoma cells. 2020 Oct 1
36 33379356 Y-Box Binding Protein-1 Promotes Epithelial-Mesenchymal Transition in Sorafenib-Resistant Hepatocellular Carcinoma Cells. 2020 Dec 28 2
37 30142009 Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody. 2019 2
38 30456603 The novel PI3K inhibitor S1 synergizes with sorafenib in non-small cell lung cancer cells involving the Akt-S6 signaling. 2019 Oct 3
39 30663411 Activation of MET promotes resistance to sorafenib in hepatocellular carcinoma cells via the AKT/ERK1/2-EGR1 pathway. 2019 Dec 2
40 30975543 Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly. 2019 May 1
41 31053148 LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells. 2019 May 3 7
42 31233189 Activation of AKT/AP1/FoxM1 signaling confers sorafenib resistance to liver cancer cells. 2019 Aug 3
43 31233204 Synergistic antitumor effect of BRMS1 and sorafenib via inhibition of the PI3K/AKT/mTOR/ERK signaling pathway. 2019 Sep 3
44 31385002 Preclinical efficacy of a novel dual PI3K/mTOR inhibitor, CMG002, alone and in combination with sorafenib in hepatocellular carcinoma. 2019 Oct 2
45 31387809 Decreased IL-6 induces sensitivity of hepatocellular carcinoma cells to sorafenib. 2019 Oct 1
46 31417635 KPNA3 Confers Sorafenib Resistance to Advanced Hepatocellular Carcinoma via TWIST Regulated Epithelial-Mesenchymal Transition. 2019 1
47 31439713 Targeting PI3K/Akt/mTOR Pathway Identifies Differential Expression and Functional Role of IL8 in Liver Cancer Stem Cell Enrichment. 2019 Nov 1
48 31698564 Bioinformatics analysis revealed hub genes and pathways involved in sorafenib resistance in hepatocellular carcinoma. 2019 Jul 8 2
49 29156516 Synergistic anticancer activity of 20(S)-Ginsenoside Rg3 and Sorafenib in hepatocellular carcinoma by modulating PTEN/Akt signaling pathway. 2018 Jan 5
50 29207150 Inhibition of autophagy enhances the targeted therapeutic effect of sorafenib in thyroid cancer. 2018 Feb 2