Methotrexate


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1686 Functionally related protein(s)
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Protein Name
UniProt Entry
Gene Symbol
Organism
NCBI Gene ID
# All related compound(s)
#Article(s)
1 dihydrofolate reductase DYR_HUMAN DHFR Homo sapiens 1719 645 401
2 tumor necrosis factor TNFA_HUMAN TNF Homo sapiens 7124 8006 309
3 metaxin 1 MTX1_HUMAN MTX1 Homo sapiens 4580 251 210
4 methylenetetrahydrofolate reductase MTHR_HUMAN MTHFR Homo sapiens 4524 396 170
5 dihydrofolate reductase DYR_MOUSE Dhfr Mus musculus 13361 182 147
6 interleukin 6 IL6_HUMAN IL6 Homo sapiens 3569 5444 80
7 tumor necrosis factor TNFA_RAT Tnf Rattus norvegicus 24835 3922 76
8 ATP binding cassette subfamily B member 1 MDR1_HUMAN ABCB1 Homo sapiens 5243 3985 75
9 thymidylate synthetase TYSY_HUMAN TYMS Homo sapiens 7298 800 74
10 C-reactive protein CRP_HUMAN CRP Homo sapiens 1401 2285 73
11 solute carrier family 19 member 1 S19A1_HUMAN SLC19A1 Homo sapiens 6573 98 71
12 dihydrofolate reductase - Dhfr Cricetulus griseus 100689028 91 70
13 folylpolyglutamate synthase FOLC_HUMAN FPGS Homo sapiens 2356 161 68
14 ATP binding cassette subfamily G member 2 (Junior blood group) ABCG2_HUMAN ABCG2 Homo sapiens 9429 1370 66
15 hypertrichosis 2 (generalised, congenital) - HTC2 Homo sapiens 3342 567 55
16 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 45
17 gamma-glutamyl hydrolase GGH_HUMAN GGH Homo sapiens 8836 236 44
18 solute carrier organic anion transporter family member 1B1 SO1B1_HUMAN SLCO1B1 Homo sapiens 10599 575 40
19 interleukin 1 beta IL1B_HUMAN IL1B Homo sapiens 3553 3575 40
20 ATP binding cassette subfamily C member 2 MRP2_HUMAN ABCC2 Homo sapiens 1244 684 37
21 catalase CATA_RAT Cat Rattus norvegicus 24248 1803 34
22 chorionic gonadotropin subunit beta 5 CGB3_HUMAN CGB5 Homo sapiens 93659 718 32
23 CD4 molecule CD4_HUMAN CD4 Homo sapiens 920 2744 32
24 replication factor C subunit 1 RFC1_HUMAN RFC1 Homo sapiens 5981 98 32
25 interleukin 1 beta Q5BKB0_RAT Il1b Rattus norvegicus 24494 2252 31
26 myeloperoxidase D3ZGE2_RAT Mpo Rattus norvegicus 303413 1141 31
27 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase PUR9_HUMAN ATIC Homo sapiens 471 229 31
28 Dihydrofolate reductase - D616_p105083 Escherichia coli 17047053 189 30
29 interleukin 6 IL6_RAT Il6 Rattus norvegicus 24498 2269 28
30 interleukin 10 IL10_HUMAN IL10 Homo sapiens 3586 2075 28
31 caspase 3 CASP3_RAT Casp3 Rattus norvegicus 25402 2178 28
32 colony stimulating factor 2 CSF2_HUMAN CSF2 Homo sapiens 1437 2088 27
33 NFE2 like bZIP transcription factor 2 NF2L2_RAT Nfe2l2 Rattus norvegicus 83619 1416 27
34 erb-b2 receptor tyrosine kinase 2 ERBB2_HUMAN ERBB2 Homo sapiens 2064 2723 27
35 tumor necrosis factor TNFA_MOUSE Tnf Mus musculus 21926 5931 26
36 BCL2 apoptosis regulator BCL2_HUMAN BCL2 Homo sapiens 596 4403 25
37 ATP binding cassette subfamily C member 2 MRP2_RAT Abcc2 Rattus norvegicus 25303 507 24
38 solute carrier family 22 member 8 S22A8_HUMAN SLC22A8 Homo sapiens 9376 404 24
39 C-X-C motif chemokine ligand 8 IL8_HUMAN CXCL8 Homo sapiens 3576 4038 24
40 albumin ALBU_HUMAN ALB Homo sapiens 213 5631 21
41 acyl-CoA synthetase bubblegum family member 1 ACBG1_HUMAN ACSBG1 Homo sapiens 23205 123 21
42 ATP binding cassette subfamily C member 4 MRP4_HUMAN ABCC4 Homo sapiens 10257 409 21
43 BCL2, apoptosis regulator BCL2_RAT Bcl2 Rattus norvegicus 24224 1676 20
44 interleukin 2 IL2_HUMAN IL2 Homo sapiens 3558 2456 20
45 ATP binding cassette subfamily C member 1 MRP1_HUMAN ABCC1 Homo sapiens 4363 1125 20
46 BCL2 associated X, apoptosis regulator G3V8T9_RAT Bax Rattus norvegicus 24887 1472 19
47 interleukin 1 alpha IL1A_HUMAN IL1A Homo sapiens 3552 2741 19
48 glutamic-oxaloacetic transaminase 2 AATM_RAT Got2 Rattus norvegicus 25721 869 19
49 solute carrier family 46 member 1 PCFT_HUMAN SLC46A1 Homo sapiens 113235 110 18
50 ATP binding cassette subfamily C member 3 MRP3_HUMAN ABCC3 Homo sapiens 8714 426 18