| 1 |
32940699 | Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis. | 2021 Mar 2 |
1 |
| 2 |
33564926 | Studies on the intracellular accumulation process of methotrexate and its correlation with the key protein using an LC-MS/MS method: a novel way to realize prospective individualized medication. | 2021 Mar |
1 |
| 3 |
31522319 | Clinico-genetic model to predict methotrexate intolerance in rheumatoid arthritis. | 2020 Jan |
3 |
| 4 |
32256983 | Enzymes involved in folate metabolism and its implication for cancer treatment. | 2020 Apr |
2 |
| 5 |
32391884 | Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia. | 2020 Sep 3 |
2 |
| 6 |
32587478 | β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB. | 2020 |
3 |
| 7 |
32694622 | FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia. | 2020 Jul 21 |
3 |
| 8 |
32793886 | Histone deacetylase inhibition enhances the therapeutic effects of methotrexate on primary central nervous system lymphoma. | 2020 Jan-Dec |
1 |
| 9 |
30851225 | SKA1 induces de novo MTX-resistance in osteosarcoma through inhibiting FPGS transcription. | 2019 Jun |
4 |
| 10 |
31008996 | Development and Validation of a Sensitive UHPLC-MS/MS-Based Method for the Analysis of Folylpolyglutamate Synthetase Enzymatic Activity in Peripheral Blood Mononuclear Cells: Application in Rheumatoid Arthritis and Leukemia Patients. | 2019 Oct |
6 |
| 11 |
31779260 | Glutamic Acid Increased Methotrexate Polyglutamation and Cytotoxicity in a CCRF-SB Acute Lymphoblastic Leukemia Cell Line. | 2019 Nov 26 |
3 |
| 12 |
29475458 | Clinical significance of polyglutamylation in primary central nervous system lymphoma. | 2018 Feb 23 |
1 |
| 13 |
28598776 | Expression of the genes facilitating methotrexate action within subcutaneous rheumatoid nodules. | 2017 Nov-Dec |
1 |
| 14 |
29095107 | SLCO1B1 rs4149056 genetic polymorphism predicting methotrexate toxicity in Chinese patients with non-Hodgkin lymphoma. | 2017 Nov |
1 |
| 15 |
26547381 | Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance. | 2016 Apr 1 |
3 |
| 16 |
26652611 | Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients. | 2016 |
2 |
| 17 |
27146084 | Sex Differences in mRNA Expression of Reduced Folate Carrier-1, Folypolyformyl Glutamate Synthase, and γ-Glutamyl Hydrolase in a Healthy Japanese Population. | 2016 Dec |
4 |
| 18 |
27980801 | Genetic polymorphisms of enzyme proteins and transporters related to methotrexate response and pharmacokinetics in a Japanese population. | 2016 |
1 |
| 19 |
27987364 | Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia. | 2016 Dec 17 |
6 |
| 20 |
24762994 | [Correlation analysis of FPGS rs10760502G>a polymorphism with prognosis and MTX-related toxicity in pediatric B-cell acute lymphoblastic leukemia]. | 2014 Apr |
3 |
| 21 |
24908438 | Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia. | 2014 Aug |
2 |
| 22 |
25013492 | Effect of folylpolyglutamate synthase A22G polymorphism on the risk and survival of patients with acute lymphoblastic leukemia. | 2014 Aug |
4 |
| 23 |
25225283 | Determinants of erythrocyte methotrexate polyglutamate levels in rheumatoid arthritis. | 2014 Nov |
2 |
| 24 |
23858048 | Expression of methotrexate transporters and metabolizing enzymes in rheumatoid synovial tissue. | 2013 Sep |
1 |
| 25 |
23949282 | Targeted expression of human folylpolyglutamate synthase for selective enhancement of methotrexate chemotherapy in osteosarcoma cells. | 2013 Sep |
2 |
| 26 |
24168269 | FPGS rs1544105 polymorphism is associated with treatment outcome in pediatric B-cell precursor acute lymphoblastic leukemia. | 2013 Oct 29 |
4 |
| 27 |
22698741 | [The mbr-FPGS efficient expression plasmid enhances the sensitivity of Jurkat cells to methotrexate]. | 2012 Jun |
10 |
| 28 |
21219404 | Influence of polymorphisms within the methotrexate pathway genes on the toxicity and efficacy of methotrexate in patients with juvenile idiopathic arthritis. | 2011 Feb |
1 |
| 29 |
21418912 | [Differential gene expression of folylpolyglutamate synthetase in cytoplasm and mitochondria in acquired methotrexate enantiomers resistant to lung cancer A549 cell lines]. | 2011 Feb 15 |
5 |
| 30 |
20072153 | Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy. | 2010 Mar |
4 |
| 31 |
19131550 | Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia. | 2009 Apr 30 |
2 |
| 32 |
19426680 | Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. | 2009 Apr 15 |
1 |
| 33 |
19902562 | Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians. | 2009 Oct |
1 |
| 34 |
18672898 | Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. | 2008 Aug 26 |
2 |
| 35 |
16884772 | Molecular basis for decreased folylpoly-gamma-glutamate synthetase expression in a methotrexate resistant CCRF-CEM mutant cell line. | 2007 Mar |
1 |
| 36 |
17286537 | Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients. | 2007 Feb |
9 |
| 37 |
18025275 | Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells. | 2007 Nov |
4 |
| 38 |
16707018 | Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells. | 2006 May 17 |
7 |
| 39 |
15542523 | Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate. | 2004 Dec |
4 |
| 40 |
12673886 | Expression of folylpolyglutamyl synthetase predicts poor response to methotrexate therapy in patients with rheumatoid arthritis. | 2003 Jan-Feb |
6 |
| 41 |
12439601 | A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia. | 2002 Nov |
1 |
| 42 |
10777604 | Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines. | 2000 Apr 28 |
2 |
| 43 |
11187907 | mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method. | 2000 Dec |
3 |
| 44 |
10029597 | Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia. | 1999 Mar 1 |
2 |
| 45 |
10470377 | Folylpoly-gamma-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity. | 1999 |
3 |
| 46 |
10499632 | Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines. | 1999 Sep |
4 |
| 47 |
10500832 | Mechanisms of methotrexate resistance in acute leukemia. Decreased transport and polyglutamylation. | 1999 |
2 |
| 48 |
10507318 | Variable expression of the folylpolyglutamate synthetase gene at the level of mRNA transcription in human leukemia cell lines sensitive, or made resistant, to various antifolate drugs. | 1999 Aug |
6 |
| 49 |
9778690 | Folylpolyglutamate synthetase expression in antifolate-sensitive and -resistant human cell lines. | 1998 |
9 |
| 50 |
9224825 | Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity. | 1997 Jul |
2 |