Protein Name ATP binding cassette subfamily C member 2
Organism Rattus norvegicus
Gene ID 25303
Gene Symbol

Abcc2

UniProt Q63120 (MRP2_RAT)
Relationships Total Number of functionally related compound(s) : 507
Total Number of Articles : 570
Description

ATP binding cassette subfamily C member 2

Gene Summary

Enables ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Involved in several processes, including carboxylic acid transport; cellular response to cytokine stimulus; and cellular response to lipid. Located in brush border membrane and intracellular canaliculus. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal disease; and visual epilepsy. Biomarker of several diseases, including bilirubin metabolic disorder; fatty liver disease; primary biliary cholangitis; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); drug-induced hepatitis; leukemia (multiple); and non-alcoholic fatty liver disease. Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • ATP-binding cassette sub-family C member 2
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 2
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Properties