CPRiL

Protein Name	ATP binding cassette subfamily C member 2
Organism	Rattus norvegicus
Gene ID	25303
Gene Symbol	Abcc2
UniProt	Q63120 (MRP2_RAT)
Relationships	Total Number of functionally related compound(s) : 507 Total Number of Articles : 570
Description	ATP binding cassette subfamily C member 2
Gene Summary	Enables ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Involved in several processes, including carboxylic acid transport; cellular response to cytokine stimulus; and cellular response to dexamethasone stimulus. Located in brush border membrane and intracellular canaliculus. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal disease; and epilepsy. Biomarker of bilirubin metabolic disorder; cholestasis; liver disease (multiple); status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2). [provided by Alliance of Genome Resources, Jun 2025]
synonyms	ATP-binding cassette sub-family C member 2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 cMrp2/cMoat canalicular apical conjugate export pump calicular multispecific organic anion transporter canalicular multidrug resistance protein canalicular multispecific organic anion transporter 1 multidrug resistance-associated protein 2 Cmoat Mrp2 cMRP mrp Click to show/hide the synonyms
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