Protein Name folylpolyglutamate synthase
Organism Homo sapiens
Gene ID 2356
Gene Symbol

FPGS

UniProt Q05932 (FOLC_HUMAN)
Relationships Total Number of functionally related compound(s) : 161
Total Number of Articles : 178
Description

folylpolyglutamate synthase

Gene Summary

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

synonyms
  • folylpolyglutamate synthase, mitochondrial
  • folylpoly-gamma-glutamate synthetase
  • tetrahydrofolate synthase
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Properties