Protein Name interleukin 10
Organism Homo sapiens
Gene ID 3586
Gene Symbol


UniProt P22301 (IL10_HUMAN), Q6FGW4 (Q6FGW4_HUMAN)
Relationships Total Number of functionally related compound(s) : 2075
Total Number of Articles : 4014

interleukin 10

Gene Summary

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]

  • interleukin-10
  • T-cell growth inhibitory factor
  • cytokine synthesis inhibitory factor
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