| 1 |
35043269 | Can we predict unresponsiveness to methotrexate in rheumatoid arthritis? A pharmacogenetic study. | 2022 Feb |
3 |
| 2 |
35586477 | Is Pharmacogenetic Panel Testing Applicable to Low-Dose Methotrexate in Rheumatoid Arthritis? - A Case Report. | 2022 |
2 |
| 3 |
33565324 | ABCB1 and SLCO1B1 gene polymorphisms predict methotrexate-resistant for low-risk gestational trophoblastic neoplasia. | 2021 Mar |
1 |
| 4 |
34744734 | The Role of Genetic Polymorphisms in High-Dose Methotrexate Toxicity and Response in Hematological Malignancies: A Systematic Review and Meta-Analysis. | 2021 |
1 |
| 5 |
32053102 | Genetic polymorphism in MDR1 C3435T is a determinant of methotrexate cerebrospinal fluid concentrations in Chinese children with acute lymphoblastic leukemia
. | 2020 May |
8 |
| 6 |
32271961 | The impacts of gene polymorphisms on methotrexate in Chinese psoriatic patients. | 2020 Sep |
2 |
| 7 |
32926395 | Validation of a Prognostic Multivariable Prediction Model for Insufficient Clinical Response to Methotrexate in Early Rheumatoid Arthritis and Its Clinical Application in Evidencio. | 2020 Dec |
1 |
| 8 |
30849662 | Ex vivo resistance in childhood acute lymphoblastic leukemia: Correlations between BCRP, MRP1, MRP4 and MRP5 ABC transporter expression and intracellular methotrexate polyglutamate accumulation. | 2019 Apr |
2 |
| 9 |
30931851 | Methotrexate Disposition in Pediatric Patients with Acute Lymphoblastic Leukemia: What Have We Learnt From the Genetic Variants of Drug Transporters. | 2019 |
1 |
| 10 |
30977678 | ABCB1 (C1236T) Polymorphism Affects P-Glycoprotein-Mediated Transport of Methotrexate, Doxorubicin, Actinomycin D, and Etoposide. | 2019 May |
8 |
| 11 |
30983549 | Association between ABCB1 C3435T polymorphism and methotrexate treatment outcomes in rheumatoid arthritis patients: a meta-analysis. | 2019 Apr |
3 |
| 12 |
31311995 | A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma. | 2019 Jul 16 |
1 |
| 13 |
31521892 | Regulation of CP-25 on P-glycoprotein in synoviocytes of rats with adjuvant arthritis. | 2019 Nov |
5 |
| 14 |
31685786 | Treatment with Methotrexate and Intravenous Cyclophosphamide Pulse Therapy Regulates the P-gp+CD4+ Cell-related Pathogenesis in a Representative Patient with Refractory Proliferative Lupus Nephritis. | 2019 |
4 |
| 15 |
31699188 | [High Expression of Multidrug Resistance Gene-1 Can Aggravate Resistance to Methotrexate in Rheumatoid Arthritis Patients]. | 2019 Oct 30 |
1 |
| 16 |
29170124 | Long non-coding RNA LUCAT1 modulates methotrexate resistance in osteosarcoma via miR-200c/ABCB1 axis. | 2018 Jan 1 |
2 |
| 17 |
29252093 | Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: A hospital based-cohort study. | 2018 Jul |
1 |
| 18 |
29670920 | Methotrexate Combined with 4-Hydroperoxycyclophosphamide Downregulates Multidrug-Resistance P-Glycoprotein Expression Induced by Methotrexate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the JAK2/STAT3 Pathway. | 2018 |
11 |
| 19 |
27751863 | Impact of genetic variants of ATP binding cassette B1, AICAR transformylase/IMP cyclohydrolase, folyl-polyglutamatesynthetase, and methylenetetrahydrofolatereductase on methotrexate toxicity. | 2017 Nov - Dec |
2 |
| 20 |
28598776 | Expression of the genes facilitating methotrexate action within subcutaneous rheumatoid nodules. | 2017 Nov-Dec |
1 |
| 21 |
28615105 | [Over-expression of mdr1/P-gp is associated with methotrexate resistance in patients with rheumatoid arthritis]. | 2017 Jun |
6 |
| 22 |
28616661 | Clinical relevance of P-glycoprotein activity on peripheral blood mononuclear cells and polymorphonuclear neutrophils to methotrexate in systemic lupus erythematosus patients. | 2017 Oct |
6 |
| 23 |
28693150 | DHFR and MDR1 upregulation is associated with chemoresistance in osteosarcoma stem-like cells. | 2017 Jul |
1 |
| 24 |
28710036 | Effect of polymorphisms in transporter genes on dosing, efficacy and toxicity of maintenance therapy in children with acute lymphoblastic leukemia. | 2017 Sep 10 |
1 |
| 25 |
26184955 | Association of the ABCB1 C3435T polymorphism with responsiveness to and toxicity of DMARDs in rheumatoid arthritis : A meta-analysis. | 2016 Sep |
3 |
| 26 |
26652611 | Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients. | 2016 |
1 |
| 27 |
27322261 | TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation. | 2016 Jun 18 |
2 |
| 28 |
27323187 | Overexpression of P-glycoprotein on fibroblast-like synoviocytes in refractory rheumatoid arthritis patients: a potential mechanism for multidrug resistance in rheumatoid arthritis treatment. | 2016 Jun 17 |
2 |
| 29 |
27533339 | Mexican Childhood Acute Lymphoblastic Leukemia: A Pilot Study of the MDR1 and MTHFR Gene Polymorphisms and Their Associations with Clinical Outcomes. | 2016 Oct |
1 |
| 30 |
27980801 | Genetic polymorphisms of enzyme proteins and transporters related to methotrexate response and pharmacokinetics in a Japanese population. | 2016 |
1 |
| 31 |
25921280 | ABCB1 polymorphisms correlate with susceptibility to adult acute leukemia and response to high-dose methotrexate. | 2015 Sep |
2 |
| 32 |
26071279 | Multidrug resistance 1 (MDR1) 3435C>T gene polymorphism influences the clinical phenotype and methotrexate-induced adverse events in South Indian Tamil rheumatoid arthritis. | 2015 Aug |
4 |
| 33 |
26353179 | Association of ABCB1, ABCC5 and xanthine oxidase genetic polymorphisms with methotrexate adverse reactions in Mexican pediatric patients with ALL. | 2015 Sep |
2 |
| 34 |
26715450 | MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients. | 2015 Dec 30 |
4 |
| 35 |
24595806 | Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1). | 2014 May |
2 |
| 36 |
24680847 | Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo. | 2014 Jun 1 |
1 |
| 37 |
25007187 | Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. | 2014 Aug |
6 |
| 38 |
25074866 | Association of MDR1 C3435T and RFC1 G80A polymorphisms with methotrexate toxicity and response in Jordanian rheumatoid arthritis patients. | 2014 Sep |
5 |
| 39 |
25303299 | Effect of polymorphisms within methotrexate pathway genes on methotrexate toxicity and plasma levels in adults with hematological malignancies. | 2014 Aug |
1 |
| 40 |
24229684 | Reversion effects of curcumin on multidrug resistance of MNNG/HOS human osteosarcoma cells in vitro and in vivo through regulation of P-glycoprotein. | 2013 Nov |
1 |
| 41 |
21887680 | Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. | 2012 Apr 1 |
1 |
| 42 |
22104130 | Genetic polymorphisms in metabolic and cellular transport pathway of methotrexate impact clinical outcome of methotrexate monotherapy in Japanese patients with rheumatoid arthritis. | 2012 |
2 |
| 43 |
22796246 | ABCB1 C3435T genetic polymorphism on population pharmacokinetics of methotrexate after hematopoietic stem cell transplantation in Korean patients: a prospective analysis. | 2012 Aug |
1 |
| 44 |
22859359 | ABCB1 and ABCC3 gene polymorphisms are associated with first-year response to methotrexate in juvenile idiopathic arthritis. | 2012 Oct |
3 |
| 45 |
23095111 | Pharmacogenetic polymorphisms contributing to toxicity induced by methotrexate in the southern Spanish population with rheumatoid arthritis. | 2012 Nov |
2 |
| 46 |
21062675 | Reversion of resistance to immunosuppressive agents in three patients with psoriatic arthritis by cyclosporine A: modulation of P-glycoprotein function. | 2011 Jan |
2 |
| 47 |
21387541 | Polymorphisms of the SLCO1B1 gene predict methotrexate-related toxicity in childhood acute lymphoblastic leukemia. | 2011 Oct |
1 |
| 48 |
21509569 | Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma. | 2011 Oct |
1 |
| 49 |
21868524 | Anti-MDR1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines. | 2011 Sep |
1 |
| 50 |
21948322 | Methotrexate-loaded chitosan- and glycol chitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors. | 2011 Dec |
1 |