| 1 |
35215593 | The Influence of Circadian Rhythm on Cancer Cells Targeting and Transfection Efficiency of a Polycation-Drug/Gene Delivery Vector. | 2022 Feb 10 |
1 |
| 2 |
33927966 | Fabrication of methotrexate-loaded gold nanoconjugates and its enhanced anticancer activity in breast cancer. | 2021 Apr |
1 |
| 3 |
33982403 | Persistent follicular granulosa cell senescence and apoptosis induced by methotrexate leading to oocyte dysfunction and aberrant embryo development. | 2021 Sep |
1 |
| 4 |
30531292 | Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations. | 2019 Apr |
3 |
| 5 |
31654627 | Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells. | 2019 Dec |
1 |
| 6 |
29554943 | Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1β on rheumatoid arthritis fibroblast-like synoviocytes. | 2018 Mar 20 |
2 |
| 7 |
29986258 | Finding the ideal polyethylenimine-plasmid DNA system for co-delivery of payloads in cancer therapy. | 2018 Oct 1 |
1 |
| 8 |
26783755 | Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner. | 2016 |
3 |
| 9 |
26920997 | Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis. | 2016 Dec |
3 |
| 10 |
27432063 | Over expression of miR-200c suppresses invasion and restores methotrexate sensitivity in lung cancer A549 cells. | 2016 Nov 30 |
1 |
| 11 |
27895503 | Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells. | 2016 |
1 |
| 12 |
26337976 | Identification of genes associated with methotrexate resistance in methotrexate-resistant osteosarcoma cell lines. | 2015 Sep 4 |
1 |
| 13 |
24525232 | Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy. | 2014 Feb 10 |
1 |
| 14 |
24967384 | Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells. | 2014 |
3 |
| 15 |
23446853 | Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells. | 2013 May |
1 |
| 16 |
22183962 | Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. | 2012 Jun |
5 |
| 17 |
21114963 | Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. | 2011 Feb 15 |
4 |
| 18 |
21810677 | Phase III study of molecularly targeted adjuvant therapy in locally advanced urothelial cancer of the bladder based on p53 status. | 2011 Sep 1 |
1 |
| 19 |
22010212 | Important role of caspase-8 for chemosensitivity of ALL cells. | 2011 Dec 15 |
2 |
| 20 |
19548002 | Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment. | 2009 Dec |
4 |
| 21 |
19731257 | The p53-mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein. | 2009 Nov |
2 |
| 22 |
20041160 | MiR-24 tumor suppressor activity is regulated independent of p53 and through a target site polymorphism. | 2009 Dec 24 |
2 |
| 23 |
17637740 | Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells. | 2008 Jan 31 |
2 |
| 24 |
19088023 | miR-192 Regulates dihydrofolate reductase and cellular proliferation through the p53-microRNA circuit. | 2008 Dec 15 |
3 |
| 25 |
17075316 | The DNA damage checkpoint is activated during residual tumour cell survival to methotrexate treatment as an initial step of acquired drug resistance. | 2006 Nov |
1 |
| 26 |
16335246 | Comparative study of p53 expression in human carcinoma cell lines A549 and MCF7 under anticancer drug treatment. | 2005 Mar-Apr |
1 |
| 27 |
15450935 | Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell. | 2004 Nov 1 |
9 |
| 28 |
11916527 | Comparison of DR5 and Fas expression levels relative to the chemosensitivity of acute lymphoblastic leukemia cell lines. | 2002 May |
1 |
| 29 |
12041674 | Epstein-Barr virus-associated B-cell type non-Hodgkin's lymphoma with concurrent p53 protein expression in a rheumatoid arthritis patient treated with methotrexate. | 2002 May |
2 |
| 30 |
11106643 | Repression of human reduced folate carrier gene expression by wild type p53. | 2001 Mar 23 |
2 |
| 31 |
10664623 | Lymphomas in patients with connective tissue disease. Comparison of p53 protein expression and latent EBV infection in patients immunosuppressed and not immunosuppressed with methotrexate. | 2000 Feb |
4 |
| 32 |
10682666 | Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients. | 2000 Feb |
2 |
| 33 |
11071927 | The tumour suppressor protein p53 can repress transcription of cyclin B. | 2000 Nov 15 |
1 |
| 34 |
10412949 | Adenovirus-mediated p53 gene therapy has greater efficacy when combined with chemotherapy against human head and neck, ovarian, prostate, and breast cancer. | 1999 |
1 |
| 35 |
9566927 | Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage. | 1998 May |
1 |
| 36 |
9584191 | Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. | 1998 Jun |
1 |
| 37 |
9649296 | Methotrexate resistance in human uroepithelial cells with p53 alterations. | 1998 Feb |
5 |
| 38 |
9681674 | Methotrexate induces apoptotic cell death in human keratinocytes. | 1998 May |
1 |
| 39 |
9771923 | Induction by estrogens of methotrexate resistance in MCF-7 breast cancer cells. | 1998 Sep |
3 |
| 40 |
8706243 | Drug-resistant breast cancer cells frequently retain expression of a functional wild-type p53 protein. | 1996 Jul |
2 |
| 41 |
7563172 | Accumulation of p53 protein as a possible predictor of response to adjuvant combination chemotherapy with cyclophosphamide, methotrexate, fluorouracil, and prednisone for breast cancer. | 1995 Aug 16 |
1 |
| 42 |
7586148 | p53 expression in normal versus transformed mammalian cells. | 1995 Oct |
1 |
| 43 |
7605998 | Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations. | 1995 Jul 15 |
1 |
| 44 |
7622024 | [p53 with a mutation in codon 273 increases the probability of amplifying the dhfr gene in Rat-1 and LIM1215 cells]. | 1995 May |
1 |
| 45 |
8579493 | [Stimulation of differentiation of LIM 1215 large intestinal tumor cells during expression of the p53 exogenous antioncogene or the activated ras oncogene]. | 1995 Sep-Oct |
2 |