Protein Name solute carrier family 46 member 1
Organism Homo sapiens
Gene ID 113235
Gene Symbol


UniProt Q96NT5 (PCFT_HUMAN), A0A024QZ44 (A0A024QZ44_HUMAN), A0A024QZ15 (A0A024QZ15_HUMAN)
Relationships Total Number of functionally related compound(s) : 110
Total Number of Articles : 148

solute carrier family 46 member 1

Gene Summary

This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

  • proton-coupled folate transporter
  • heme carrier protein 1
  • solute carrier family 46 (folate transporter), member 1
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