| Protein Name | colony stimulating factor 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1437 |
| Gene Symbol | CSF2 |
| UniProt | P04141 (CSF2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
2088
Total Number of Articles : 4283 |
Description |
colony stimulating factor 2 |
| Gene Summary |
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis. [provided by RefSeq, Aug 2020] |
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