Protein Name colony stimulating factor 2
Organism Homo sapiens
Gene ID 1437
Gene Symbol


UniProt P04141 (CSF2_HUMAN)
Relationships Total Number of functionally related compound(s) : 2088
Total Number of Articles : 4283

colony stimulating factor 2

Gene Summary

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis. [provided by RefSeq, Aug 2020]

  • granulocyte-macrophage colony-stimulating factor
  • colony stimulating factor 2 (granulocyte-macrophage)
  • granulocyte macrophage-colony stimulating factor
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