CPRiL

Protein Name	replication factor C subunit 1
Organism	Homo sapiens
Gene ID	5981
Gene Symbol	RFC1
UniProt	P35251 (RFC1_HUMAN)
Relationships	Total Number of functionally related compound(s) : 98 Total Number of Articles : 139
Description	replication factor C subunit 1
Gene Summary	This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
synonyms	replication factor C subunit 1 A1 140 kDa subunit DNA-binding protein PO-GA MHC binding factor, beta RF-C 140 kDa subunit activator 1 140 kDa subunit activator 1 large subunit activator 1 subunit 1 replication factor C (activator 1) 1, 145kDa replication factor C 140 kDa subunit replication factor C large subunit replication factor C1 A1 CANVAS MHCBFB PO-GA RECC1 RFC RFC140 Click to show/hide the synonyms
Properties