Protein Name replication factor C subunit 1
Organism Homo sapiens
Gene ID 5981
Gene Symbol


UniProt P35251 (RFC1_HUMAN)
Relationships Total Number of functionally related compound(s) : 98
Total Number of Articles : 139

replication factor C subunit 1

Gene Summary

This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]

  • replication factor C subunit 1
  • A1 140 kDa subunit
  • DNA-binding protein PO-GA
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