CPRiL

Nfe2l2

NFE2 like bZIP transcription factor 2

Enables transcription cis-regulatory region binding activity and transcription coregulator binding activity. Involved in several processes, including aflatoxin catabolic process; positive regulation of macromolecule biosynthetic process; and regulation of cell migration. Located in nucleus. Used to study diabetic retinopathy; liver disease (multiple); middle cerebral artery infarction; myocardial infarction; and pulmonary fibrosis. Biomarker of several diseases, including extrahepatic cholestasis; kidney failure (multiple); metabolic dysfunction-associated steatohepatitis; neurodegenerative disease (multiple); and traumatic brain injury. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2). [provided by Alliance of Genome Resources, Jun 2025]

• nuclear factor erythroid 2-related factor 2
• NF-E2-related factor 2
• NFE2-related factor 2
nrf2
nuclear factor, erythroid 2-like 2
nuclear factor, erythroid derived 2, like 2