Protein Name NFE2 like bZIP transcription factor 2
Organism Rattus norvegicus
Gene ID 83619
Gene Symbol


UniProt O54968 (NF2L2_RAT)
Relationships Total Number of functionally related compound(s) : 1416
Total Number of Articles : 2572

NFE2 like bZIP transcription factor 2

Gene Summary

Enables transcription cis-regulatory region binding activity and transcription coregulator binding activity. Involved in several processes, including aflatoxin catabolic process; positive regulation of macromolecule metabolic process; and regulation of cell migration. Located in cytoplasm and nucleus. Used to study several diseases, including diabetic retinopathy; liver cirrhosis; middle cerebral artery infarction; non-alcoholic fatty liver disease; and visual epilepsy. Biomarker of several diseases, including extrahepatic cholestasis; kidney failure (multiple); neurodegenerative disease (multiple); non-alcoholic steatohepatitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

  • nuclear factor erythroid 2-related factor 2
  • NF-E2-related factor 2
  • NFE2-related factor 2
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