| Protein Name | BCL2 associated X, apoptosis regulator |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24887 |
| Gene Symbol | Bax |
| UniProt | G3V8T9 (G3V8T9_RAT), Q9JKL3 (Q9JKL3_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
1472
Total Number of Articles : 3067 |
Description |
BCL2 associated X, apoptosis regulator |
| Gene Summary |
Enables BH domain binding activity; chaperone binding activity; and heat shock protein binding activity. Involved in several processes, including glial cell apoptotic process; mitochondrion organization; and response to corticosterone. Located in cytosol; mitochondrial outer membrane; and perinuclear region of cytoplasm. Used to study brain glioma; endometriosis; morphine dependence; and pre-malignant neoplasm. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain disease (multiple); heart disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; colorectal cancer; and lung non-small cell carcinoma. Orthologous to human BAX (BCL2 associated X, apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022] |
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