Protein Name dihydrofolate reductase
Organism Mus musculus
Gene ID 13361
Gene Symbol

Dhfr

UniProt P00375 (DYR_MOUSE), Q544T5 (Q544T5_MOUSE)
Relationships Total Number of functionally related compound(s) : 182
Total Number of Articles : 248
Description

dihydrofolate reductase

Gene Summary

Enables dihydrofolate reductase activity. Involved in several processes, including positive regulation of nitric-oxide synthase activity; tetrahydrobiopterin biosynthetic process; and tetrahydrofolate interconversion. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including DHFRP1 (dihydrofolate reductase pseudogene 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • dihydrofolate reductase
  • 8430436I03Rik
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Properties