Afatinib


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236 Functionally related protein(s)
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Protein Name
UniProt Entry
Gene Symbol
Organism
NCBI Gene ID
# All related compound(s)
#Article(s)
1 epidermal growth factor receptor EGFR_HUMAN EGFR Homo sapiens 1956 4580 839
2 erb-b2 receptor tyrosine kinase 2 ERBB2_HUMAN ERBB2 Homo sapiens 2064 2723 172
3 erb-b2 receptor tyrosine kinase 4 ERBB4_HUMAN ERBB4 Homo sapiens 2066 169 42
4 epidermal growth factor receptor EGFR_MOUSE Egfr Mus musculus 13649 981 32
5 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 27
6 erb-b2 receptor tyrosine kinase 3 ERBB3_HUMAN ERBB3 Homo sapiens 2065 299 23
7 KRAS proto-oncogene, GTPase RASK_HUMAN KRAS Homo sapiens 3845 1547 12
8 ALK receptor tyrosine kinase ALK_HUMAN ALK Homo sapiens 238 603 9
9 neuregulin 1 NRG1_HUMAN NRG1 Homo sapiens 3084 229 9
10 ATP binding cassette subfamily G member 2 (Junior blood group) ABCG2_HUMAN ABCG2 Homo sapiens 9429 1370 8
11 mechanistic target of rapamycin kinase MTOR_HUMAN MTOR Homo sapiens 2475 3411 8
12 erb-b2 receptor tyrosine kinase 2 ERBB2_MOUSE Erbb2 Mus musculus 13866 567 8
13 signal transducer and activator of transcription 3 STAT3_HUMAN STAT3 Homo sapiens 6774 2503 8
14 ATP binding cassette subfamily B member 1 MDR1_HUMAN ABCB1 Homo sapiens 5243 3985 7
15 MET proto-oncogene, receptor tyrosine kinase MET_HUMAN MET Homo sapiens 4233 791 7
16 SRC proto-oncogene, non-receptor tyrosine kinase SRC_HUMAN SRC Homo sapiens 6714 2142 6
17 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 6
18 mitogen-activated protein kinase 1 MK01_HUMAN MAPK1 Homo sapiens 5594 4181 5
19 epidermal growth factor EGF_HUMAN EGF Homo sapiens 1950 1636 5
20 EPH receptor B2 EPHB2_HUMAN EPHB2 Homo sapiens 2048 321 5
21 proprotein convertase subtilisin/kexin type 9 PCSK9_HUMAN PCSK9 Homo sapiens 255738 518 4
22 B-Raf proto-oncogene, serine/threonine kinase BRAF_HUMAN BRAF Homo sapiens 673 872 4
23 mitogen-activated protein kinase kinase 7 MP2K7_HUMAN MAP2K7 Homo sapiens 5609 1407 4
24 insulin like growth factor 1 receptor IGF1R_HUMAN IGF1R Homo sapiens 3480 814 4
25 SAFB like transcription modulator SLTM_HUMAN SLTM Homo sapiens 79811 394 3
26 epidermal growth factor receptor Q9QX70_RAT Egfr Rattus norvegicus 24329 495 3
27 phosphatase and tensin homolog PTEN_HUMAN PTEN Homo sapiens 5728 1316 3
28 vascular endothelial growth factor A VEGFA_HUMAN VEGFA Homo sapiens 7422 4023 3
29 NRAS proto-oncogene, GTPase RASN_HUMAN NRAS Homo sapiens 4893 357 3
30 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PK3CA_HUMAN PIK3CA Homo sapiens 5290 683 3
31 latexin LXN_HUMAN LXN Homo sapiens 56925 5329 3
32 protein tyrosine kinase 2 FAK1_HUMAN PTK2 Homo sapiens 5747 1151 3
33 Kirsten rat sarcoma viral oncogene homolog RASK_MOUSE Kras Mus musculus 16653 464 3
34 hepatocyte growth factor HGF_HUMAN HGF Homo sapiens 3082 1036 3
35 serpin family B member 3 SPB3_HUMAN SERPINB3 Homo sapiens 6317 583 3
36 protein tyrosine kinase 2 beta FAK2_HUMAN PTK2B Homo sapiens 2185 848 2
37 phosphoglycolate phosphatase PGP_MOUSE Pgp Mus musculus 67078 756 2
38 protein phosphatase 2 phosphatase activator PTPA_HUMAN PTPA Homo sapiens 5524 675 2
39 thymoma viral proto-oncogene 1 AKT1_MOUSE Akt1 Mus musculus 11651 3034 2
40 fibroblast growth factor receptor 1 FGFR1_HUMAN FGFR1 Homo sapiens 2260 405 2
41 mitogen-activated protein kinase 14 MK14_HUMAN MAPK14 Homo sapiens 1432 3132 2
42 cadherin 1 CADH1_HUMAN CDH1 Homo sapiens 999 1360 2
43 cyclin dependent kinase inhibitor 2A ARF_HUMAN CDKN2A Homo sapiens 1029 859 2
44 ret proto-oncogene RET_HUMAN RET Homo sapiens 5979 674 2
45 transformation related protein 53, pseudogene - Trp53-ps Mus musculus 22060 1552 2
46 interleukin 6 IL6_HUMAN IL6 Homo sapiens 3569 5444 2
47 eukaryotic translation initiation factor 2A EIF2A_HUMAN EIF2A Homo sapiens 83939 566 2
48 CEA cell adhesion molecule 3 CEAM3_HUMAN CEACAM3 Homo sapiens 1084 1053 2
49 TSC complex subunit 1 TSC1_HUMAN TSC1 Homo sapiens 7248 220 2
50 interleukin 6 receptor IL6RA_HUMAN IL6R Homo sapiens 3570 248 2