| Protein Name | erb-b2 receptor tyrosine kinase 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13866 |
| Gene Symbol | Erbb2 |
| UniProt | P70424 (ERBB2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
567
Total Number of Articles : 751 |
Description |
erb-b2 receptor tyrosine kinase 2 |
| Gene Summary |
Enables coreceptor activity and protein tyrosine kinase activity. Involved in several processes, including ERBB2 signaling pathway; nervous system development; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Part of semaphorin receptor complex. Is active in neuromuscular junction and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including lung cancer (multiple); mammary Paget's disease; reproductive organ cancer (multiple); stomach cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Jun 2025] |
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