| Protein Name | protein phosphatase 2 phosphatase activator |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5524 |
| Gene Symbol | PTPA |
| UniProt | Q15257 (PTPA_HUMAN), F6WIT2 (F6WIT2_HUMAN), B4DZF8 (B4DZF8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
675
Total Number of Articles : 1345 |
Description |
protein phosphatase 2 phosphatase activator |
| Gene Summary |
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
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