| Protein Name | epidermal growth factor receptor |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13649 |
| Gene Symbol | Egfr |
| UniProt | Q01279 (EGFR_MOUSE), Q9EP98 (Q9EP98_MOUSE), Q9WVF5 (Q9WVF5_MOUSE), Q3TQS6 (Q3TQS6_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
981
Total Number of Articles : 1570 |
Description |
epidermal growth factor receptor |
| Gene Summary |
Enables epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in several processes, including ERBB2-EGFR signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including eyelid development in camera-type eye; positive regulation of epidermal growth factor receptor signaling pathway; and ubiquitin-dependent endocytosis. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and sensory organ. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Jun 2025] |
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