Protein Name epidermal growth factor receptor
Organism Mus musculus
Gene ID 13649
Gene Symbol

Egfr

UniProt Q01279 (EGFR_MOUSE), Q9EP98 (Q9EP98_MOUSE), Q9WVF5 (Q9WVF5_MOUSE), Q3TQS6 (Q3TQS6_MOUSE)
Relationships Total Number of functionally related compound(s) : 981
Total Number of Articles : 1570
Description

epidermal growth factor receptor

Gene Summary

Enables epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in cellular response to amino acid stimulus and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; epidermal growth factor receptor signaling pathway; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and respiratory system. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • epidermal growth factor receptor
  • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
  • waved 2
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Properties