| Protein Name | eukaryotic translation initiation factor 2A |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 83939 |
| Gene Symbol | EIF2A |
| UniProt | Q9BY44 (EIF2A_HUMAN), F8WAE5 (F8WAE5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
566
Total Number of Articles : 840 |
Description |
eukaryotic translation initiation factor 2A |
| Gene Summary |
This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
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| Properties | |