Protein Name NRAS proto-oncogene, GTPase
Organism Homo sapiens
Gene ID 4893
Gene Symbol

NRAS

UniProt P01111 (RASN_HUMAN), Q5U091 (Q5U091_HUMAN)
Relationships Total Number of functionally related compound(s) : 357
Total Number of Articles : 481
Description

NRAS proto-oncogene, GTPase

Gene Summary

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

synonyms
  • GTPase NRas
  • N-ras protein part 4
  • neuroblastoma RAS viral (v-ras) oncogene homolog
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Properties