Protein Name ALK receptor tyrosine kinase
Organism Homo sapiens
Gene ID 238
Gene Symbol


UniProt Q9UM73 (ALK_HUMAN), B6D4Y2 (B6D4Y2_HUMAN)
Relationships Total Number of functionally related compound(s) : 603
Total Number of Articles : 2295

ALK receptor tyrosine kinase

Gene Summary

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

  • ALK tyrosine kinase receptor
  • CD246 antigen
  • anaplastic lymphoma receptor tyrosine kinase
Click to show/hide the synonyms