Protein Name epidermal growth factor
Organism Homo sapiens
Gene ID 1950
Gene Symbol


UniProt P01133 (EGF_HUMAN)
Relationships Total Number of functionally related compound(s) : 1636
Total Number of Articles : 3073

epidermal growth factor

Gene Summary

This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

  • pro-epidermal growth factor
  • beta-urogastrone
  • HOMG4
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