Protein Name epidermal growth factor receptor
Organism Rattus norvegicus
Gene ID 24329
Gene Symbol

Egfr

UniProt Q9QX70 (Q9QX70_RAT)
Relationships Total Number of functionally related compound(s) : 495
Total Number of Articles : 731
Description

epidermal growth factor receptor

Gene Summary

Enables several functions, including calmodulin binding activity; epidermal growth factor binding activity; and epidermal growth factor-activated receptor activity. Involved in several processes, including animal organ development; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Used to study bronchiolo-alveolar adenocarcinoma; dilated cardiomyopathy; and high grade glioma. Biomarker of several diseases, including Parkinsonism; acute kidney failure; lung disease (multiple); median neuropathy; and peptic esophagitis. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • epidermal growth factor receptor
  • EGFR-related peptide
  • Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
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Properties