| Protein Name | epidermal growth factor receptor |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24329 |
| Gene Symbol | Egfr |
| UniProt | Q9QX70 (Q9QX70_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
495
Total Number of Articles : 731 |
Description |
epidermal growth factor receptor |
| Gene Summary |
Enables several functions, including calmodulin binding activity; enzyme binding activity; and epidermal growth factor binding activity. Involved in several processes, including blood vessel diameter maintenance; positive regulation of cell communication; and protein phosphorylation. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Is active in glutamatergic synapse and synaptic membrane. Used to study bronchiolo-alveolar adenocarcinoma; dilated cardiomyopathy; and high grade glioma. Biomarker of several diseases, including Parkinsonism; lung disease (multiple); median neuropathy; nicotine dependence; and peptic esophagitis. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Jul 2025] |
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