| Protein Name | AXL receptor tyrosine kinase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 558 |
| Gene Symbol | AXL |
| UniProt | P30530 (UFO_HUMAN), M0R0W6 (M0R0W6_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
302
Total Number of Articles : 493 |
Description |
AXL receptor tyrosine kinase |
| Gene Summary |
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021] |
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