AZD 6244


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284 Functionally related protein(s)
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Protein Name
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UniProt Entry
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Gene Symbol
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Organism
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NCBI Gene ID
# All related compound(s)
#Article(s)
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1 mitogen-activated protein kinase kinase 7 MP2K7_HUMAN MAP2K7 Homo sapiens 5609 1407 201
2 mitogen-activated protein kinase kinase 1 MP2K1_HUMAN MAP2K1 Homo sapiens 5604 739 150
3 mitogen-activated protein kinase 1 MK01_HUMAN MAPK1 Homo sapiens 5594 4181 60
4 KRAS proto-oncogene, GTPase RASK_HUMAN KRAS Homo sapiens 3845 1547 51
5 B-Raf proto-oncogene, serine/threonine kinase BRAF_HUMAN BRAF Homo sapiens 673 872 46
6 mitogen-activated protein kinase 3 MK03_HUMAN MAPK3 Homo sapiens 5595 3238 34
7 neurofibromin 1 NF1_HUMAN NF1 Homo sapiens 4763 413 30
8 midkine MK_MOUSE Mdk Mus musculus 17242 501 29
9 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 26
10 epidermal growth factor receptor EGFR_HUMAN EGFR Homo sapiens 1956 4580 17
11 zinc fingers and homeoboxes 2 ZHX2_HUMAN ZHX2 Homo sapiens 22882 627 14
12 mitogen-activated protein kinase 1 MK01_MOUSE Mapk1 Mus musculus 26413 1992 13
13 mitogen-activated protein kinase kinase 1 MP2K1_MOUSE Map2k1 Mus musculus 26395 224 13
14 NRAS proto-oncogene, GTPase RASN_HUMAN NRAS Homo sapiens 4893 357 10
15 mitogen-activated protein kinase kinase 2 MP2K2_HUMAN MAP2K2 Homo sapiens 5605 75 9
16 eukaryotic translation initiation factor 2 alpha kinase 3 E2AK3_HUMAN EIF2AK3 Homo sapiens 9451 737 8
17 Kirsten rat sarcoma viral oncogene homolog RASK_MOUSE Kras Mus musculus 16653 464 8
18 mitogen-activated protein kinase 3 MK03_MOUSE Mapk3 Mus musculus 26417 1527 6
19 cyclin D1 CCND1_HUMAN CCND1 Homo sapiens 595 1747 5
20 erb-b2 receptor tyrosine kinase 2 ERBB2_HUMAN ERBB2 Homo sapiens 2064 2723 5
21 signal transducer and activator of transcription 3 STAT3_HUMAN STAT3 Homo sapiens 6774 2503 5
22 vascular endothelial growth factor A VEGFA_HUMAN VEGFA Homo sapiens 7422 4023 4
23 caspase 3 CASP3_HUMAN CASP3 Homo sapiens 836 5209 4
24 checkpoint kinase 1 CHK1_HUMAN CHEK1 Homo sapiens 1111 648 4
25 mitogen-activated protein kinase 12 MK12_HUMAN MAPK12 Homo sapiens 6300 55 4
26 mechanistic target of rapamycin kinase MTOR_HUMAN MTOR Homo sapiens 2475 3411 4
27 G protein subunit alpha q GNAQ_HUMAN GNAQ Homo sapiens 2776 150 4
28 epidermal growth factor receptor EGFR_MOUSE Egfr Mus musculus 13649 981 3
29 cyclin dependent kinase inhibitor 1A CDN1A_HUMAN CDKN1A Homo sapiens 1026 1631 3
30 ribosomal protein S6 kinase B1 KS6B1_HUMAN RPS6KB1 Homo sapiens 6198 764 3
31 interferon gamma IFNG_HUMAN IFNG Homo sapiens 3458 3371 3
32 hypoxia inducible factor 1 subunit alpha HIF1A_HUMAN HIF1A Homo sapiens 3091 2152 3
33 BCL2 like 11 B2L11_HUMAN BCL2L11 Homo sapiens 10018 399 3
34 MCL1 apoptosis regulator, BCL2 family member MCL1_HUMAN MCL1 Homo sapiens 4170 1015 3
35 mechanistic target of rapamycin kinase MTOR_MOUSE Mtor Mus musculus 56717 1120 3
36 Braf transforming gene BRAF_MOUSE Braf Mus musculus 109880 159 3
37 BCL2 apoptosis regulator BCL2_HUMAN BCL2 Homo sapiens 596 4403 3
38 CD274 molecule PD1L1_HUMAN CD274 Homo sapiens 29126 1115 3
39 lamin A/C LMNA_HUMAN LMNA Homo sapiens 4000 356 3
40 BH3 interacting domain death agonist BID_HUMAN BID Homo sapiens 637 1130 3
41 proprotein convertase subtilisin/kexin type 9 PCSK9_HUMAN PCSK9 Homo sapiens 255738 518 3
42 forkhead box O3 FOXO3_HUMAN FOXO3 Homo sapiens 2309 544 3
43 thymoma viral proto-oncogene 1 AKT1_MOUSE Akt1 Mus musculus 11651 3034 3
44 CREB regulated transcription coactivator 1 CRTC1_HUMAN CRTC1 Homo sapiens 23373 120 2
45 tumor necrosis factor TNFA_MOUSE Tnf Mus musculus 21926 5931 2
46 SRC proto-oncogene, non-receptor tyrosine kinase SRC_HUMAN SRC Homo sapiens 6714 2142 2
47 tumor necrosis factor TNFA_HUMAN TNF Homo sapiens 7124 8006 2
48 MYC proto-oncogene, bHLH transcription factor MYC_HUMAN MYC Homo sapiens 4609 2261 2
49 Fos proto-oncogene, AP-1 transcription factor subunit FOS_HUMAN FOS Homo sapiens 2353 1431 2
50 Rous sarcoma oncogene SRC_MOUSE Src Mus musculus 20779 497 2