Protein Name BCL2 like 11
Organism Homo sapiens
Gene ID 10018
Gene Symbol


UniProt O43521 (B2L11_HUMAN), A0A0A0MRE7 (A0A0A0MRE7_HUMAN), A0A0C4DH20 (A0A0C4DH20_HUMAN)
Relationships Total Number of functionally related compound(s) : 399
Total Number of Articles : 543

BCL2 like 11

Gene Summary

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

  • bcl-2-like protein 11
  • BCL2-like 11 (apoptosis facilitator)
  • bcl-2 interacting mediator of cell death
Click to show/hide the synonyms