AZD 6244

mitogen-activated protein kinase 3 ; Mus musculus







6 Article(s)
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Title
Pub. Year
#Total Relationships
1 25326806 Combine MEK inhibition with PI3K/mTOR inhibition exert inhibitory tumor growth effect on KRAS and PIK3CA mutation CRC xenografts due to reduced expression of VEGF and matrix metallopeptidase-9. 2015 Feb 1
2 25541062 AZD6244 inhibits cisplatin-induced ERK1/2 activation and potentiates cisplatin-associated cytotoxicity in K-ras G12D preclinical models. 2015 Mar 1 1
3 23815988 Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation. 2013 Jul 1 1
4 22068161 Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene. 2012 Feb 1 1
5 17237274 Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. 2007 Jan 2
6 17876044 AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma. 2007 Sep 1