AZD 6244

zinc fingers and homeoboxes 2 ; Homo sapiens







14 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 32181767 [vestigation of molecular factors determining BRAF-inhibitor sensitivity in solid tumors]. 2020 Mar 17 1
2 32336014 RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K-RAS mutant tumors. 2020 Aug 1
3 30846494 Histone deacetylase inhibition in combination with MEK or BCL-2 inhibition in multiple myeloma. 2019 Oct 2
4 28424891 A phase I dose-escalation study of Selumetinib in combination with Erlotinib or Temsirolimus in patients with advanced solid tumors. 2017 Oct 3
5 28620782 Role of key genetic mutations on increasing migration of brain cancer cells through confinement. 2017 Sep 1
6 26802155 Selumetinib with and without erlotinib in KRAS mutant and KRAS wild-type advanced nonsmall-cell lung cancer. 2016 Apr 3
7 25933683 Dual blockade of PI3K/AKT/mTOR (NVP-BEZ235) and Ras/Raf/MEK (AZD6244) pathways synergistically inhibit growth of primary endometrioid endometrial carcinoma cultures, whereas NVP-BEZ235 reduces tumor growth in the corresponding xenograft models. 2015 Jul 1
8 26250606 Synergistic anticancer efficacy of MEK inhibition and dual PI3K/mTOR inhibition in castration-resistant prostate cancer. 2015 Nov 1
9 25199829 RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells. 2014 Sep 11 1
10 23414467 Selumetinib: a promising pharmacologic approach for KRAS-mutant advanced non-small-cell lung cancer. 2013 Feb 1
11 23372439 (18)F-FLT-PET for Response Evaluation of MEK Inhibitor Selumetinib (AZD6244, ARRY-142886) in Patients with Solid Tumors. 2012 May 3
12 21910575 Inhibitor of MEK1/2, selumetinib, for biliary tract cancer. 2011 Oct 1
13 20587667 Identification of common predictive markers of in vitro response to the Mek inhibitor selumetinib (AZD6244; ARRY-142886) in human breast cancer and non-small cell lung cancer cell lines. 2010 Jul 1
14 18676837 BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins. 2008 Aug 1 1