Protein Name Rous sarcoma oncogene
Organism Mus musculus
Gene ID 20779
Gene Symbol


UniProt P05480 (SRC_MOUSE)
Relationships Total Number of functionally related compound(s) : 497
Total Number of Articles : 815

Rous sarcoma oncogene

Gene Summary

Enables several functions, including connexin binding activity; ephrin receptor binding activity; and scaffold protein binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; positive regulation of signal transduction; and protein destabilization. Acts upstream of or within several processes, including animal organ development; cellular response to growth factor stimulus; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; focal adhesion; and ruffle membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and retina. Used to study Williams-Beuren syndrome. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

  • proto-oncogene tyrosine-protein kinase Src
  • neuronal proto-oncogene tyrosine-protein kinase Src
  • p60-Src
Click to show/hide the synonyms