2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine


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126 Functionally related protein(s)
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Protein Name
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UniProt Entry
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Gene Symbol
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Organism
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NCBI Gene ID
# All related compound(s)
#Article(s)
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1 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 18
2 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PK3CA_HUMAN PIK3CA Homo sapiens 5290 683 17
3 mechanistic target of rapamycin kinase MTOR_HUMAN MTOR Homo sapiens 2475 3411 13
4 mitogen-activated protein kinase kinase 7 MP2K7_HUMAN MAP2K7 Homo sapiens 5609 1407 12
5 erb-b2 receptor tyrosine kinase 2 ERBB2_HUMAN ERBB2 Homo sapiens 2064 2723 11
6 mitogen-activated protein kinase 1 MK01_HUMAN MAPK1 Homo sapiens 5594 4181 6
7 MCL1 apoptosis regulator, BCL2 family member MCL1_HUMAN MCL1 Homo sapiens 4170 1015 5
8 phosphatase and tensin homolog PTEN_HUMAN PTEN Homo sapiens 5728 1316 5
9 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PK3CD_HUMAN PIK3CD Homo sapiens 5293 775 4
10 erb-b2 receptor tyrosine kinase 3 ERBB3_HUMAN ERBB3 Homo sapiens 2065 299 4
11 thymoma viral proto-oncogene 1 AKT1_MOUSE Akt1 Mus musculus 11651 3034 4
12 epidermal growth factor receptor EGFR_HUMAN EGFR Homo sapiens 1956 4580 3
13 BCL2 associated X, apoptosis regulator BAX_HUMAN BAX Homo sapiens 581 3031 3
14 annexin A5 ANXA5_HUMAN ANXA5 Homo sapiens 308 1785 2
15 pyruvate dehydrogenase kinase 1 PDK1_HUMAN PDK1 Homo sapiens 5163 414 2
16 tumor necrosis factor TNFA_MOUSE Tnf Mus musculus 21926 5931 2
17 MYC proto-oncogene, bHLH transcription factor MYC_HUMAN MYC Homo sapiens 4609 2261 2
18 caspase 3 CASP3_HUMAN CASP3 Homo sapiens 836 5209 2
19 serum/glucocorticoid regulated kinase family member 3 SGK3_HUMAN SGK3 Homo sapiens 23678 39 2
20 phosphatase and tensin homolog PTEN_MOUSE Pten Mus musculus 19211 532 2
21 myeloid cell leukemia sequence 1 MCL1_MOUSE Mcl1 Mus musculus 17210 147 2
22 FMS-like tyrosine kinase 3 FLT3_MOUSE Flt3 Mus musculus 14255 153 2
23 ribosomal protein S6 kinase, polypeptide 1 KS6B1_MOUSE Rps6kb1 Mus musculus 72508 289 2
24 cyclin D1 CCND1_HUMAN CCND1 Homo sapiens 595 1747 2
25 vascular endothelial growth factor A VEGFA_HUMAN VEGFA Homo sapiens 7422 4023 2
26 Pim-1 proto-oncogene, serine/threonine kinase PIM1_HUMAN PIM1 Homo sapiens 5292 562 2
27 eukaryotic translation initiation factor 4E binding protein 1 4EBP1_HUMAN EIF4EBP1 Homo sapiens 1978 300 2
28 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 2
29 ATM serine/threonine kinase ATM_HUMAN ATM Homo sapiens 472 847 2
30 cytochrome P450 family 19 subfamily A member 1 CP19A_HUMAN CYP19A1 Homo sapiens 1588 827 1
31 SRC proto-oncogene, non-receptor tyrosine kinase SRC_HUMAN SRC Homo sapiens 6714 2142 1
32 epidermal growth factor EGF_HUMAN EGF Homo sapiens 1950 1636 1
33 lysosomal associated membrane protein 1 LAMP1_HUMAN LAMP1 Homo sapiens 3916 224 1
34 granzyme B GRAB_HUMAN GZMB Homo sapiens 3002 426 1
35 interferon gamma IFNG_HUMAN IFNG Homo sapiens 3458 3371 1
36 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 NFKB1_MOUSE Nfkb1 Mus musculus 18033 3161 1
37 CD8a molecule CD8A_HUMAN CD8A Homo sapiens 925 1925 1
38 O-6-methylguanine-DNA methyltransferase MGMT_HUMAN MGMT Homo sapiens 4255 549 1
39 ATR serine/threonine kinase ATR_HUMAN ATR Homo sapiens 545 866 1
40 CD1c molecule CD1C_HUMAN CD1C Homo sapiens 911 272 1
41 heat shock protein 90 alpha family class A member 1 HS90A_HUMAN HSP90AA1 Homo sapiens 3320 1552 1
42 Kirsten rat sarcoma viral oncogene homolog RASK_MOUSE Kras Mus musculus 16653 464 1
43 myeloproliferative leukemia virus oncogene TPOR_MOUSE Mpl Mus musculus 17480 74 1
44 poly(ADP-ribose) polymerase 1 PARP1_HUMAN PARP1 Homo sapiens 142 2571 1
45 BCL2 apoptosis regulator BCL2_HUMAN BCL2 Homo sapiens 596 4403 1
46 ATP-binding cassette, sub-family B (MDR/TAP), member 1A MDR1A_MOUSE Abcb1a Mus musculus 18671 272 1
47 KRAS proto-oncogene, GTPase RASK_HUMAN KRAS Homo sapiens 3845 1547 1
48 insulin like growth factor 1 receptor IGF1R_HUMAN IGF1R Homo sapiens 3480 814 1
49 zinc fingers and homeoboxes 2 ZHX2_MOUSE Zhx2 Mus musculus 387609 161 1
50 ETS transcription factor ERG ERG_HUMAN ERG Homo sapiens 2078 1044 1