2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine


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126 Functionally related protein(s)
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Protein Name
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UniProt Entry
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Gene Symbol
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Organism
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NCBI Gene ID
# All related compound(s)
#Article(s)
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1 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 18
2 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PK3CA_HUMAN PIK3CA Homo sapiens 5290 683 17
3 mechanistic target of rapamycin kinase MTOR_HUMAN MTOR Homo sapiens 2475 3411 13
4 mitogen-activated protein kinase kinase 7 MP2K7_HUMAN MAP2K7 Homo sapiens 5609 1407 12
5 erb-b2 receptor tyrosine kinase 2 ERBB2_HUMAN ERBB2 Homo sapiens 2064 2723 11
6 mitogen-activated protein kinase 1 MK01_HUMAN MAPK1 Homo sapiens 5594 4181 6
7 MCL1 apoptosis regulator, BCL2 family member MCL1_HUMAN MCL1 Homo sapiens 4170 1015 5
8 phosphatase and tensin homolog PTEN_HUMAN PTEN Homo sapiens 5728 1316 5
9 thymoma viral proto-oncogene 1 AKT1_MOUSE Akt1 Mus musculus 11651 3034 4
10 erb-b2 receptor tyrosine kinase 3 ERBB3_HUMAN ERBB3 Homo sapiens 2065 299 4
11 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PK3CD_HUMAN PIK3CD Homo sapiens 5293 775 4
12 epidermal growth factor receptor EGFR_HUMAN EGFR Homo sapiens 1956 4580 3
13 BCL2 associated X, apoptosis regulator BAX_HUMAN BAX Homo sapiens 581 3031 3
14 pyruvate dehydrogenase kinase 1 PDK1_HUMAN PDK1 Homo sapiens 5163 414 2
15 cyclin D1 CCND1_HUMAN CCND1 Homo sapiens 595 1747 2
16 MYC proto-oncogene, bHLH transcription factor MYC_HUMAN MYC Homo sapiens 4609 2261 2
17 Pim-1 proto-oncogene, serine/threonine kinase PIM1_HUMAN PIM1 Homo sapiens 5292 562 2
18 ribosomal protein S6 kinase, polypeptide 1 KS6B1_MOUSE Rps6kb1 Mus musculus 72508 289 2
19 serum/glucocorticoid regulated kinase family member 3 SGK3_HUMAN SGK3 Homo sapiens 23678 39 2
20 phosphatase and tensin homolog PTEN_MOUSE Pten Mus musculus 19211 532 2
21 vascular endothelial growth factor A VEGFA_HUMAN VEGFA Homo sapiens 7422 4023 2
22 eukaryotic translation initiation factor 4E binding protein 1 4EBP1_HUMAN EIF4EBP1 Homo sapiens 1978 300 2
23 annexin A5 ANXA5_HUMAN ANXA5 Homo sapiens 308 1785 2
24 caspase 3 CASP3_HUMAN CASP3 Homo sapiens 836 5209 2
25 tumor necrosis factor TNFA_MOUSE Tnf Mus musculus 21926 5931 2
26 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 2
27 FMS-like tyrosine kinase 3 FLT3_MOUSE Flt3 Mus musculus 14255 153 2
28 ATM serine/threonine kinase ATM_HUMAN ATM Homo sapiens 472 847 2
29 myeloid cell leukemia sequence 1 MCL1_MOUSE Mcl1 Mus musculus 17210 147 2
30 macrophage stimulating 1 HGFL_HUMAN MST1 Homo sapiens 4485 148 1
31 erb-b2 receptor tyrosine kinase 2 ERBB2_MOUSE Erbb2 Mus musculus 13866 567 1
32 colony stimulating factor 2 CSF2_HUMAN CSF2 Homo sapiens 1437 2088 1
33 interferon gamma IFNG_MOUSE Ifng Mus musculus 15978 2936 1
34 zinc fingers and homeoboxes 2 ZHX2_HUMAN ZHX2 Homo sapiens 22882 627 1
35 cytochrome P450 family 19 subfamily A member 1 CP19A_HUMAN CYP19A1 Homo sapiens 1588 827 1
36 O-linked N-acetylglucosamine (GlcNAc) transferase OGT1_HUMAN OGT Homo sapiens 8473 454 1
37 epidermal growth factor EGF_HUMAN EGF Homo sapiens 1950 1636 1
38 death associated protein DAP1_HUMAN DAP Homo sapiens 1611 395 1
39 lysosomal associated membrane protein 1 LAMP1_HUMAN LAMP1 Homo sapiens 3916 224 1
40 protein tyrosine kinase 2 beta FAK2_HUMAN PTK2B Homo sapiens 2185 848 1
41 granzyme B GRAB_HUMAN GZMB Homo sapiens 3002 426 1
42 SRC proto-oncogene, non-receptor tyrosine kinase SRC_HUMAN SRC Homo sapiens 6714 2142 1
43 interferon gamma IFNG_HUMAN IFNG Homo sapiens 3458 3371 1
44 nuclear receptor subfamily 4 group A member 1 NR4A1_HUMAN NR4A1 Homo sapiens 3164 657 1
45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 NFKB1_MOUSE Nfkb1 Mus musculus 18033 3161 1
46 interleukin 6 IL6_MOUSE Il6 Mus musculus 16193 3985 1
47 CD8a molecule CD8A_HUMAN CD8A Homo sapiens 925 1925 1
48 ectonucleotide pyrophosphatase/phosphodiesterase 3 ENPP3_HUMAN ENPP3 Homo sapiens 5169 188 1
49 fibronectin 1 FINC_HUMAN FN1 Homo sapiens 2335 2017 1
50 MX dynamin-like GTPase 1 MX1B_MOUSE Mx1 Mus musculus 17857 41 1