Protein Name O-linked N-acetylglucosamine (GlcNAc) transferase
Organism Homo sapiens
Gene ID 8473
Gene Symbol


UniProt O15294 (OGT1_HUMAN)
Relationships Total Number of functionally related compound(s) : 454
Total Number of Articles : 840

O-linked N-acetylglucosamine (GlcNAc) transferase

Gene Summary

This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

  • UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
  • O-GlcNAc transferase p110 subunit
  • O-GlcNAc transferase subunit p110
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