Protein Name pyruvate dehydrogenase kinase 1
Organism Homo sapiens
Gene ID 5163
Gene Symbol

PDK1

UniProt Q15118 (PDK1_HUMAN), B7Z7N6 (B7Z7N6_HUMAN)
Relationships Total Number of functionally related compound(s) : 414
Total Number of Articles : 549
Description

pyruvate dehydrogenase kinase 1

Gene Summary

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]

synonyms
  • [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
  • pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial
  • PDH kinase 1
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Properties