CPRiL

Nfkb1

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and transcription coregulator activity. Involved in several processes, including B cell receptor signaling pathway; cellular response to virus; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to tumor necrosis factor; regulation of gene expression; and response to muscle stretch. Located in cytosol. Part of NF-kappaB p50/p65 complex and transcription regulator complex. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis; carcinoma (multiple); common variable immunodeficiency 12; melanoma; and prostate cancer. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Jun 2025]

• nuclear factor NF-kappa-B p105 subunit
• DNA-binding factor KBF1
• EBP-1
NF kappaB1
NF-kappa-B1 p84/NF-kappa-B1 p98
NF-kappaB p50
nuclear factor kappaB p50
nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
p50 subunit of NF kappaB
NF-KB1
NF-kappaB
NF-kappaB1
p105
p50
p50/p105