| Protein Name | myeloid cell leukemia sequence 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 17210 |
| Gene Symbol | Mcl1 |
| UniProt | P97287 (MCL1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
147
Total Number of Articles : 161 |
Description |
myeloid cell leukemia sequence 1 |
| Gene Summary |
Enables BH3 domain binding activity. Involved in extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of apoptotic process; and positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; blastocyst; central nervous system; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung cancer; and lung non-small cell carcinoma. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member). [provided by Alliance of Genome Resources, Jul 2025] |
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