Protein Name Pim-1 proto-oncogene, serine/threonine kinase
Organism Homo sapiens
Gene ID 5292
Gene Symbol


UniProt P11309 (PIM1_HUMAN), A0A024RD25 (A0A024RD25_HUMAN)
Relationships Total Number of functionally related compound(s) : 562
Total Number of Articles : 559

Pim-1 proto-oncogene, serine/threonine kinase

Gene Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

  • serine/threonine-protein kinase pim-1
  • Oncogene PIM1
  • pim-1 oncogene (proviral integration site 1)
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