| Protein Name | Pim-1 proto-oncogene, serine/threonine kinase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5292 |
| Gene Symbol | PIM1 |
| UniProt | P11309 (PIM1_HUMAN), A0A024RD25 (A0A024RD25_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
562
Total Number of Articles : 559 |
Description |
Pim-1 proto-oncogene, serine/threonine kinase |
| Gene Summary |
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011] |
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