Protein Name granzyme B
Organism Homo sapiens
Gene ID 3002
Gene Symbol


UniProt P10144 (GRAB_HUMAN), J3KQ52 (J3KQ52_HUMAN), Q6XGZ4 (Q6XGZ4_HUMAN), Q67BC3 (Q67BC3_HUMAN)
Relationships Total Number of functionally related compound(s) : 426
Total Number of Articles : 458

granzyme B

Gene Summary

This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]

  • granzyme B
  • T-cell serine protease 1-3E
  • cathepsin G-like 1
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