2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine

mitogen-activated protein kinase kinase 7 ; Homo sapiens







12 Article(s)
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PMID
Title
Pub. Year
#Total Relationships
1 34837846 High-throughput ex vivo drug testing identifies potential drugs and drug combinations for NRAS-positive malignant melanoma. 2022 Jan 1
2 30795621 The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells. 2019 Feb 21 2
3 28808038 The Phosphatidylinositol 3-Kinase Pathway as a Potential Therapeutic Target in Bladder Cancer. 2017 Nov 1 2
4 25855885 Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies. 2015 Jun 1
5 22801959 Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas. 2013 Jan 1
6 23053270 PK-PD modeling of combination efficacy effect from administration of the MEK inhibitor GDC-0973 and PI3K inhibitor GDC-0941 in A2058 xenografts. 2013 Jan 1
7 23602735 Synergistic inhibition of thyroid cancer by suppressing MAPK/PI3K/AKT pathways. 2013 Oct 1
8 24004591 [Growth inhibition of combined pathway inhibitors on KRAS mutated non-small cell lung cancer cell line]. 2013 May 1
9 24218548 Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition. 2013 Nov 26 1
10 22101421 The novel dual PI3K/mTOR inhibitor GDC-0941 synergizes with the MEK inhibitor U0126 in non-small cell lung cancer cells. 2012 Feb 1
11 22415236 The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition. 2012 Apr 10 1
12 19509167 Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab. 2009 Jun 15 1