2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine

AKT serine/threonine kinase 1 ; Homo sapiens







18 Article(s)
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Pub. Year
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1 34735897 A novel strategy for combination of clofarabine and pictilisib is synergistic in gastric cancer. 2022 Jan 1
2 32514232 Virtual docking screening and QSAR studies to explore AKT and mTOR inhibitors acting on PI3K in cancers. 2020 1
3 33659212 Pictilisib Enhances the Antitumor Effect of Doxorubicin and Prevents Tumor-Mediated Bone Destruction by Blockade of PI3K/AKT Pathway. 2020 2
4 31553879 Preclinical Evaluation of a Fluorine-18 (18F)-Labeled Phosphatidylinositol 3-Kinase Inhibitor for Breast Cancer Imaging. 2019 Nov 4 1
5 28029662 Guidance to rational use of pharmaceuticals in gallbladder sarcomatoid carcinoma using patient-derived cancer cells and whole exome sequencing. 2017 Jan 17 3
6 28291364 Multifunctional Nanoparticles Loading with Docetaxel and GDC0941 for Reversing Multidrug Resistance Mediated by PI3K/Akt Signal Pathway. 2017 Apr 3 1
7 28536078 AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes. 2017 Jul 15 1
8 27465249 PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma. 2016 Jul 28 1
9 25370471 First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors. 2015 Jan 1 1
10 25941816 Ellagic Acid Enhances the Efficacy of PI3K Inhibitor GDC-0941 in Breast Cancer Cells. 2015 1
11 24601221 More antitumor efficacy of the PI3K inhibitor GDC-0941 in breast cancer with PIK3CA mutation or HER2 amplification status in vitro. 2014 Jan 1
12 23602735 Synergistic inhibition of thyroid cancer by suppressing MAPK/PI3K/AKT pathways. 2013 Oct 2
13 23711387 Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance. 2013 Nov 2
14 23006739 The antitumor effect of GDC-0941 alone and in combination with rapamycin in breast cancer cells. 2012 2
15 21994956 GDC-0941 inhibits metastatic characteristics of thyroid carcinomas by targeting both the phosphoinositide-3 kinase (PI3K) and hypoxia-inducible factor-1α (HIF-1α) pathways. 2011 Dec 1
16 20361045 Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. 2010 Mar 26 2
17 20826841 Nuclear phospho-Akt increase predicts synergy of PI3K inhibition and doxorubicin in breast and ovarian cancer. 2010 Sep 8 1
18 19382889 High-throughput screening compatible cell-based assay for interrogating activated notch signaling. 2009 Feb 1