Protein Name cytochrome P450 family 19 subfamily A member 1
Organism Homo sapiens
Gene ID 1588
Gene Symbol


UniProt P11511 (CP19A_HUMAN), A0A024R5S8 (A0A024R5S8_HUMAN), Q05CU4 (Q05CU4_HUMAN), A8K6W3 (A8K6W3_HUMAN), Q8TCA4 (Q8TCA4_HUMAN), Q8IYG4 (Q8IYG4_HUMAN)
Relationships Total Number of functionally related compound(s) : 827
Total Number of Articles : 1149

cytochrome P450 family 19 subfamily A member 1

Gene Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

  • aromatase
  • cytochrome P-450AROM
  • cytochrome P450 19A1
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