ibrutinib


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453 Functionally related protein(s)
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Protein Name
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UniProt Entry
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Gene Symbol
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Organism
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NCBI Gene ID
# All related compound(s)
#Article(s)
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1 Bruton tyrosine kinase BTK_HUMAN BTK Homo sapiens 695 383 664
2 Bruton agammaglobulinemia tyrosine kinase BTK_MOUSE Btk Mus musculus 12229 162 79
3 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 51
4 MYD88 innate immune signal transduction adaptor MYD88_HUMAN MYD88 Homo sapiens 4615 440 40
5 C-X-C motif chemokine receptor 4 CXCR4_HUMAN CXCR4 Homo sapiens 7852 1170 32
6 phospholipase C gamma 2 PLCG2_HUMAN PLCG2 Homo sapiens 5336 125 30
7 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 27
8 inhibitor of Bruton tyrosine kinase IBTK_HUMAN IBTK Homo sapiens 25998 23 26
9 IL2 inducible T cell kinase ITK_HUMAN ITK Homo sapiens 3702 387 25
10 BCL2 apoptosis regulator BCL2_HUMAN BCL2 Homo sapiens 596 4403 24
11 epidermal growth factor receptor EGFR_HUMAN EGFR Homo sapiens 1956 4580 17
12 cytochrome P450 family 3 subfamily A member 4 CP3A4_HUMAN CYP3A4 Homo sapiens 1576 3475 14
13 MYC proto-oncogene, bHLH transcription factor MYC_HUMAN MYC Homo sapiens 4609 2261 13
14 CD19 molecule CD19_HUMAN CD19 Homo sapiens 930 398 12
15 mechanistic target of rapamycin kinase MTOR_HUMAN MTOR Homo sapiens 2475 3411 11
16 solute carrier family 35 member B2 S35B2_HUMAN SLC35B2 Homo sapiens 347734 19 11
17 nuclear factor kappa B subunit 1 NFKB1_HUMAN NFKB1 Homo sapiens 4790 4834 11
18 spleen associated tyrosine kinase KSYK_HUMAN SYK Homo sapiens 6850 486 10
19 IL2 inducible T cell kinase ITK_MOUSE Itk Mus musculus 16428 143 10
20 interleukin 10 IL10_HUMAN IL10 Homo sapiens 3586 2075 10
21 signal transducer and activator of transcription 3 STAT3_HUMAN STAT3 Homo sapiens 6774 2503 9
22 erb-b2 receptor tyrosine kinase 2 ERBB2_HUMAN ERBB2 Homo sapiens 2064 2723 9
23 keratin 20 K1C20_HUMAN KRT20 Homo sapiens 54474 544 9
24 immunoglobulin heavy variable 3-69-1 (pseudogene) - IGHV3-69-1 Homo sapiens 28402 39 9
25 receptor tyrosine kinase like orphan receptor 1 ROR1_HUMAN ROR1 Homo sapiens 4919 81 8
26 thymoma viral proto-oncogene 1 AKT1_MOUSE Akt1 Mus musculus 11651 3034 8
27 interleukin 6 IL6_HUMAN IL6 Homo sapiens 3569 5444 8
28 BCR activator of RhoGEF and GTPase BCR_HUMAN BCR Homo sapiens 613 263 7
29 BMX non-receptor tyrosine kinase BMX_HUMAN BMX Homo sapiens 660 80 7
30 MCL1 apoptosis regulator, BCL2 family member MCL1_HUMAN MCL1 Homo sapiens 4170 1015 7
31 BCL2 like 1 B2CL1_HUMAN BCL2L1 Homo sapiens 598 1360 7
32 CD79b molecule CD79B_HUMAN CD79B Homo sapiens 974 102 7
33 tumor necrosis factor TNFA_HUMAN TNF Homo sapiens 7124 8006 7
34 tec protein tyrosine kinase TEC_HUMAN TEC Homo sapiens 7006 54 6
35 C-X-C motif chemokine ligand 12 SDF1_HUMAN CXCL12 Homo sapiens 6387 628 6
36 ATP binding cassette subfamily B member 6 (Langereis blood group) ABCB6_HUMAN ABCB6 Homo sapiens 10058 793 6
37 mitogen-activated protein kinase 1 MK01_HUMAN MAPK1 Homo sapiens 5594 4181 6
38 fms related receptor tyrosine kinase 3 FLT3_HUMAN FLT3 Homo sapiens 2322 569 6
39 IKAROS family zinc finger 2 IKZF2_HUMAN IKZF2 Homo sapiens 22807 25 6
40 caspase recruitment domain family member 11 CAR11_HUMAN CARD11 Homo sapiens 84433 23 5
41 glycoprotein VI platelet GPVI_HUMAN GP6 Homo sapiens 51206 181 5
42 ATP binding cassette subfamily B member 1 MDR1_HUMAN ABCB1 Homo sapiens 5243 3985 5
43 CD274 antigen PD1L1_MOUSE Cd274 Mus musculus 60533 466 5
44 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PK3CD_HUMAN PIK3CD Homo sapiens 5293 775 5
45 DNA damage inducible transcript 3 DDIT3_HUMAN DDIT3 Homo sapiens 1649 1082 5
46 CD274 molecule PD1L1_HUMAN CD274 Homo sapiens 29126 1115 5
47 CD8a molecule CD8A_HUMAN CD8A Homo sapiens 925 1925 5
48 C-C motif chemokine ligand 3 CCL3_HUMAN CCL3 Homo sapiens 6348 580 5
49 CD4 molecule CD4_HUMAN CD4 Homo sapiens 920 2744 5
50 NLR family, pyrin domain containing 3 NLRP3_MOUSE Nlrp3 Mus musculus 216799 1325 4