Protein Name IL2 inducible T cell kinase
Organism Mus musculus
Gene ID 16428
Gene Symbol

Itk

UniProt Q03526 (ITK_MOUSE), Q5STT8 (Q5STT8_MOUSE), Q5STT7 (Q5STT7_MOUSE), A1A560 (A1A560_MOUSE), Q3U5G1 (Q3U5G1_MOUSE)
Relationships Total Number of functionally related compound(s) : 143
Total Number of Articles : 141
Description

IL2 inducible T cell kinase

Gene Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including T cell receptor signaling pathway; gamma-delta T cell activation; and protein phosphorylation. Acts upstream of or within NK T cell differentiation. Located in cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • tyrosine-protein kinase ITK/TSK
  • T-cell-specific kinase
  • interleukin-2-inducible T cell kinase
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Properties