ibrutinib

tumor protein p53 ; Homo sapiens







51 Article(s)
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1 34791836 Identification of a genetic signature enriching for response to ibrutinib in relapsed/refractory follicular lymphoma in the DAWN phase 2 trial. 2022 Jan 1
2 34865212 Long-term efficacy of first-line ibrutinib treatment for chronic lymphocytic leukaemia in patients with TP53 aberrations: a pooled analysis from four clinical trials. 2022 Feb 2
3 33735664 Molecular and genetic biomarkers implemented from next-generation sequencing provide treatment insights in clinical practice for Waldenström macroglobulinemia. 2021 Apr 1
4 33963002 Clinical Outcomes in Patients with Multi-Hit TP53 Chronic Lymphocytic Leukemia Treated with Ibrutinib. 2021 Aug 15 2
5 34127506 TP53 Disruption in Chronic Lymphocytic Leukemia Under Ibrutinib: More is Worse? 2021 Aug 15 3
6 34521099 Ibrutinib induces durable remissions in treatment-naïve patients with CLL and 17p deletion and/or TP53 mutations. 2021 Dec 16 3
7 31180577 Dissection of subclonal evolution by temporal mutation profiling in chronic lymphocytic leukemia patients treated with ibrutinib. 2020 Jan 1 1
8 31628428 Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL: 5 years of follow-up from the phase 3 RESONATE-2 study. 2020 Mar 1
9 31732977 Ibrutinib in the treatment of chronic lymphocytic leukemia: 5 years on. 2020 Apr 2
10 31924585 PRIMA-1MET cytotoxic effect correlates with p53 protein reduction in TP53-mutated chronic lymphocytic leukemia cells. 2020 Feb 1
11 31965420 Effective upfront treatment with low-dose ibrutinib for a patient with B cell prolymphocytic leukemia. 2020 Oct 2
12 32172299 Chronic Lymphocytic Leukaemia in 2020: the Future Has Arrived. 2020 Mar 14 1
13 32187452 The impact of dose modification and temporary interruption of ibrutinib on outcomes of chronic lymphocytic leukemia patients in routine clinical practice. 2020 May 1
14 32726539 Ibrutinib for Chronic Lymphocytic Leukemia with TP53 Alterations. 2020 Jul 30 1
15 32791549 [Current diagnosis and treatment of chronic lymphocytic leukaemia]. 2020 Aug 2
16 32833105 LPL deletion is associated with poorer response to ibrutinib-based treatments and overall survival in TP53-deleted chronic lymphocytic leukemia. 2020 Oct 2
17 32994268 Transformation to plasmablastic lymphoma in CLL upon ibrutinib treatment. 2020 Sep 29 1
18 30183082 TP53 mutations are associated with mutated MYD88 and CXCR4, and confer an adverse outcome in Waldenström macroglobulinaemia. 2019 Jan 1
19 30338509 Unravelling the suboptimal response of TP53-mutated chronic lymphocytic leukaemia to ibrutinib. 2019 Feb 5
20 30559058 Aggressive Leukemic Non-Nodal Mantle Cell Lymphoma With P53 Gene Rearrangement/Mutation is Highly Responsive to Rituximab/Ibrutinib Combination Therapy. 2019 Feb 1
21 30842083 Long-term follow-up of the RESONATE phase 3 trial of ibrutinib vs ofatumumab. 2019 May 9 1
22 30988561 Reduced Dose Ibrutinib Due to Financial Toxicity in CLL. 2019 Apr 1
23 31363127 Bruton's tyrosine kinase is at the crossroads of metabolic adaptation in primary malignant human lymphocytes. 2019 Jul 30 1
24 31555576 Minimal Residual Disease in Chronic Lymphocytic Leukemia: A New Goal? 2019 1
25 31648477 [Ibrutinib combined with CAR-T cells in the treatment of del (17p) chronic lymphocytic leukemia with BCL-2 inhibitor resistance: a case report and literature review]. 2019 Sep 14 1
26 28549767 Treatment of Del17p and/or aberrant TP53 chronic lymphocytic leukemia in the era of novel therapies. 2018 Mar 1
27 29480432 Frontline Therapy of CLL: Evolving Treatment Paradigm. 2018 Apr 1
28 29484684 Clinical, pathological, and biological characterization of Richter syndrome developing after ibrutinib treatment for relapsed chronic lymphocytic leukemia. 2018 Feb 27 1
29 30175400 Long-term outcomes and mutation profiling of patients with mantle cell lymphoma (MCL) who discontinued ibrutinib. 2018 Nov 2
30 27535981 Cell-Intrinsic Determinants of Ibrutinib-Induced Apoptosis in Chronic Lymphocytic Leukemia. 2017 Feb 15 4
31 27797975 Long-term Follow-up of Treatment with Ibrutinib and Rituximab in Patients with High-Risk Chronic Lymphocytic Leukemia. 2017 May 1 1
32 28130034 NICE guidance on ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia in the presence of 17p deletion or TP53 mutation. 2017 Mar 1
33 28185174 Current Treatment of Chronic Lymphocytic Leukemia. 2017 Jan 1
34 28782884 Chronic lymphocytic leukemia: 2017 update on diagnosis, risk stratification, and treatment. 2017 Sep 1
35 29082795 Treatment approach for elderly and unfit patients with chronic lymphocytic leukemia. 2017 Dec 1
36 29222275 The mutational landscape of chronic lymphocytic leukemia and its impact on prognosis and treatment. 2017 Dec 8 1
37 29234595 Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature. 2017 1
38 29250930 Management of high risk chronic lymphocytic leukaemia (CLL) patients in Australia. 2017 Dec 1
39 27040702 Initial therapy of chronic lymphocytic leukemia. 2016 Apr 1
40 27198718 Real-world results of ibrutinib in patients with relapsed or refractory chronic lymphocytic leukemia: data from 95 consecutive patients treated in a compassionate use program. A study from the Swedish Chronic Lymphocytic Leukemia Group. 2016 Dec 1
41 27284738 p53-independent ibrutinib responses in an Eμ-TCL1 mouse model demonstrates efficacy in high-risk CLL. 2016 Jun 10 2
42 27913471 Sequencing of chronic lymphocytic leukemia therapies. 2016 Dec 2 1
43 25555420 Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trial. 2015 Feb 3
44 25802231 Ibrutinib: a review of its use in patients with mantle cell lymphoma or chronic lymphocytic leukaemia. 2015 May 2
45 25908509 Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment. 2015 May 1
46 26062943 Ibrutinib, idelalisib and obinutuzumab for the treatment of patients with chronic lymphocytic leukemia: three new arrows aiming at the target. 2015 1
47 26118882 [Ibrutinib: A new drug of B-cell malignancies]. 2015 Jun 1
48 26628631 The role of B-cell receptor inhibitors in the treatment of patients with chronic lymphocytic leukemia. 2015 Dec 1
49 26637744 Management of prolymphocytic leukemia. 2015 1
50 26637745 Prognostic markers and standard management of chronic lymphocytic leukemia. 2015 1