Protein Name DNA damage inducible transcript 3
Organism Homo sapiens
Gene ID 1649
Gene Symbol


UniProt P35638 (DDIT3_HUMAN), Q53YD1 (Q53YD1_HUMAN)
Relationships Total Number of functionally related compound(s) : 1082
Total Number of Articles : 2317

DNA damage inducible transcript 3

Gene Summary

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

  • DNA damage-inducible transcript 3 protein
  • C/EBP zeta
  • CCAAT/enhancer-binding protein homologous protein
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