Protein Name glycoprotein VI platelet
Organism Homo sapiens
Gene ID 51206
Gene Symbol

GP6

UniProt Q9HCN6 (GPVI_HUMAN)
Relationships Total Number of functionally related compound(s) : 181
Total Number of Articles : 220
Description

glycoprotein VI platelet

Gene Summary

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

synonyms
  • platelet glycoprotein VI
  • glycoprotein 6
  • platelet collagen receptor
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Properties