Protein Name C-X-C motif chemokine ligand 12
Organism Homo sapiens
Gene ID 6387
Gene Symbol


UniProt P48061 (SDF1_HUMAN)
Relationships Total Number of functionally related compound(s) : 628
Total Number of Articles : 978

C-X-C motif chemokine ligand 12

Gene Summary

This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

  • stromal cell-derived factor 1
  • chemokine (C-X-C motif) ligand 12
  • intercrine reduced in hepatomas
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