Protein Name CD274 antigen
Organism Mus musculus
Gene ID 60533
Gene Symbol

Cd274

UniProt Q9EP73 (PD1L1_MOUSE), Q3U472 (Q3U472_MOUSE)
Relationships Total Number of functionally related compound(s) : 466
Total Number of Articles : 501
Description

CD274 antigen

Gene Summary

The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]

synonyms
  • programmed cell death 1 ligand 1
  • B7 homolog 1
  • PDCD1 ligand 1
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Properties