ibrutinib

C-X-C motif chemokine receptor 4 ; Homo sapiens







32 Article(s)
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1 34965304 Response and survival predictors in a cohort of 319 patients with Waldenström macroglobulinemia treated with ibrutinib monotherapy. 2022 Feb 8 1
2 33669329 Targeting of CXCR4 by the Naturally Occurring CXCR4 Antagonist EPI-X4 in Waldenström's Macroglobulinemia. 2021 Feb 16 1
3 33735664 Molecular and genetic biomarkers implemented from next-generation sequencing provide treatment insights in clinical practice for Waldenström macroglobulinemia. 2021 Apr 1
4 34289017 Phase 1 study of ibrutinib and the CXCR4 antagonist ulocuplumab in CXCR4-mutated Waldenström macroglobulinemia. 2021 Oct 28 1
5 32083995 Genomic Landscape of Waldenström Macroglobulinemia and Its Impact on Treatment Strategies. 2020 Apr 10 1
6 32580942 In Human Visualization of Ibrutinib-Induced CLL Compartment Shift. 2020 Aug 1
7 32647793 Response and Survival Outcomes to Ibrutinib Monotherapy for Patients With Waldenström Macroglobulinemia on and off Clinical Trials. 2020 Jun 1
8 31267520 CXCR4 mutation subtypes impact response and survival outcomes in patients with Waldenström macroglobulinaemia treated with ibrutinib. 2019 Nov 5
9 31343930 CXCR4 mutations affect presentation and outcomes in patients with Waldenström macroglobulinemia: A systematic review. 2019 Oct 1
10 31570491 CXCR4 S338X clonality is an important determinant of ibrutinib outcomes in patients with Waldenström macroglobulinemia. 2019 Oct 8 1
11 31695539 Evaluating ibrutinib in the treatment of symptomatic Waldenstrom's macroglobulinemia. 2019 1
12 29280186 Ibrutinib discontinuation in Waldenström macroglobulinemia: Etiologies, outcomes, and IgM rebound. 2018 Aug 1
13 29326436 p66Shc deficiency enhances CXCR4 and CCR7 recycling in CLL B cells by facilitating their dephosphorylation-dependent release from β-arrestin at early endosomes. 2018 Mar 2
14 29869556 A head-to-head Phase III study comparing zanubrutinib versus ibrutinib in patients with Waldenström macroglobulinemia. 2018 Sep 1
15 30044692 Ibrutinib Monotherapy in Symptomatic, Treatment-Naïve Patients With Waldenström Macroglobulinemia. 2018 Sep 20 1
16 30190015 Working Toward a Genomic Prognostic Classification of Waldenström Macroglobulinemia: C-X-C Chemokine Receptor Type 4 Mutation and Beyond. 2018 Oct 1
17 28235842 Acquired mutations associated with ibrutinib resistance in Waldenström macroglobulinemia. 2017 May 4 1
18 28294689 Genomics, Signaling, and Treatment of Waldenström Macroglobulinemia. 2017 Mar 20 3
19 28548645 Waldenstrom macroglobulinemia cells devoid of BTKC481S or CXCR4WHIM-like mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment. 2017 May 26 1
20 28641100 Bruton's tyrosine kinase (BTK) as a promising target in solid tumors. 2017 Jul 1
21 28641630 [SDF-1α/CXCR4 Mediated Drug Resistance Can be Reversed by Ibrutinib in Acute Lymphoblastic Leukemia]. 2017 Jun 7
22 29365396 [Ibrutinib inhibits mesenchymal stem cells-mediated drug resistance in diffuse large B-cell lymphoma]. 2017 Dec 14 6
23 27268124 Clinical Validation of a CXCR4 Mutation Screening Assay for Waldenstrom Macroglobulinemia. 2016 Jul 1
24 27287071 Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status. 2016 Dec 15 1
25 27480113 Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis. 2016 Sep 22 1
26 31360080 Waldenström macroglobulinemia: biology, genetics, and therapy. 2016 1
27 24912431 The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia. 2015 Jan 5
28 25371371 CXCR4 WHIM-like frameshift and nonsense mutations promote ibrutinib resistance but do not supplant MYD88(L265P) -directed survival signalling in Waldenström macroglobulinaemia cells. 2015 Mar 8
29 25853747 Ibrutinib in previously treated Waldenström's macroglobulinemia. 2015 Apr 9 1
30 26138997 Ibrutinib for the treatment of Waldenström macroglobulinemia. 2015 Oct 1
31 26282174 Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia. 2015 Oct 1 1
32 25294819 Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML. 2014 Oct 30 2