| Protein Name | BCR activator of RhoGEF and GTPase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 613 |
| Gene Symbol | BCR |
| UniProt | P11274 (BCR_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
263
Total Number of Articles : 631 |
Description |
BCR activator of RhoGEF and GTPase |
| Gene Summary |
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020] |
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