CPRiL

Btk

Bruton agammaglobulinemia tyrosine kinase

Enables protein tyrosine kinase activity. Involved in negative regulation of cytokine production and positive regulation of NLRP3 inflammasome complex assembly. Acts upstream of or within several processes, including B cell affinity maturation; cellular response to interleukin-7; and negative regulation of B cell proliferation. Located in cytoplasmic vesicle; membrane raft; and nucleus. Is expressed in liver left lobe; liver right lobe; spleen; and thymus primordium. Used to study X-linked agammaglobulinemia. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human BTK (Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Jun 2025]

• tyrosine-protein kinase BTK
• ATK
• B-cell progenitor kinase
BPK
Bruton's tyrosine kinase
Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB)
X-linked immune deficiency
agammaglobulinaemia tyrosine kinase
agammaglobulinemia tyrosine kinase
bruton tyrosine kinase
kinase EMB
xid